Reorganization of the intact somatosensory cortex immediately after spinal cord injury.
Reorganization of the intact somatosensory cortex immediately after spinal cord injury.
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DOI：
10.1371/journal.pone.0069655
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Foffani G
中科院分区：
文献类型：
--
作者：
Humanes-Valera D;Aguilar J;Foffani G
感觉传入神经阻滞导致相应传入阻滞皮层的广泛重组。然而，人们对相邻完整皮层在这种重组中的作用知之甚少。在这里，我们表明，脊髓的完整胸段横断立即增加了麻醉大鼠完整前爪皮质对前爪刺激（病变水平之上）的反应。这些增加的前爪反应与我们之前的工作（Aguilar 等人，J Neurosci 2010）中描述的脊髓横断引起的皮质状态的整体变化无关，因为当皮质处于沉默状态（下状态）或活跃状态（上状态）时，反应都会增加。完整的前爪皮层的反应增加与传入神经缺失的后爪皮层的反应增加相关，这表明它们可以代表脊髓损伤后初级体感皮层的相同即时状态独立功能重组的不同观点。总的来说，本研究和我们之前的研究结果表明，状态依赖和状态独立机制可以共同促进脊髓损伤后立即进行皮质重组。
Sensory deafferentation produces extensive reorganization of the corresponding deafferented cortex. Little is known, however, about the role of the adjacent intact cortex in this reorganization. Here we show that a complete thoracic transection of the spinal cord immediately increases the responses of the intact forepaw cortex to forepaw stimuli (above the level of the lesion) in anesthetized rats. These increased forepaw responses were independent of the global changes in cortical state induced by the spinal cord transection described in our previous work (Aguilar et al., J Neurosci 2010), as the responses increased both when the cortex was in a silent state (down-state) or in an active state (up-state). The increased responses in the intact forepaw cortex correlated with increased responses in the deafferented hindpaw cortex, suggesting that they could represent different points of view of the same immediate state-independent functional reorganization of the primary somatosensory cortex after spinal cord injury. Collectively, the results of the present study and of our previous study suggest that both state-dependent and state-independent mechanisms can jointly contribute to cortical reorganization immediately after spinal cord injury.
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影响因子：
2.2
作者：
Foffani, G.;Humanes-Valera, D.;Aguilar, J.
通讯作者：
Aguilar, J.
影响因子：
3.4
作者：
Erchova, IA;Lebedev, MA;Diamond, ME
通讯作者：
Diamond, ME
影响因子：
2.5
作者：
Favero, Morgana;Varghese, Gladis;Castro-Alamancos, Manuel A.
通讯作者：
Castro-Alamancos, Manuel A.
影响因子：
7.4
作者：
Carlton SM;Du J;Tan HY;Nesic O;Hargett GL;Bopp AC;Yamani A;Lin Q;Willis WD;Hulsebosch CE
通讯作者：
Hulsebosch CE
影响因子：
5.3
作者：
DOSTROVSKY, JO;MILLAR, J;WALL, PD
通讯作者：
WALL, PD