Oral fluid and plasma 3,4-methylenedioxymethamphetamine (MDMA) and metabolite correlation after controlled oral MDMA administration.
Oral fluid and plasma 3,4-methylenedioxymethamphetamine (MDMA) and metabolite correlation after controlled oral MDMA administration.
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DOI：
10.1007/s00216-013-6848-7
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发表时间：
2013-05
影响因子：
4.3
通讯作者：
Huestis, Marilyn A.
中科院分区：
文献类型：
--
作者：
Desrosiers, Nathalie A.;Barnes, Allan J.;Hartman, Rebecca L.;Scheidweiler, Karl B.;Kolbrich-Spargo, Erin A.;Gorelick, David A.;Goodwin, Robert S.;Huestis, Marilyn A.
口腔液（OF）为药物检测提供了非侵入性样本采集。然而，与血浆相比，OF中的3，4-亚甲二氧基甲基苯丙胺（MDMA，摇头丸）尚未得到充分表征。我们给予口服低（1.0 mg/kg）和高（1.6 mg/kg）剂量MDMA的26名参与者，并收集同步的OF和血浆标本长达143小时后给药。我们比较了OF/血浆（OF/P）比值、初始检测时间（tfirst）、最大浓度（Cmax）、达峰时间（tmax）、末次检测时间（tlast）、清除率和3，4-亚甲二氧基苯丙胺（MDA）与MDMA比值随时间的变化。与血浆相比，OF MDMA和MDA的Cmax较高，tlast较晚，清除较慢。仅对于OF MDA，将tfirst与血浆进行比较。MDMA和MDA的中位（范围）OF/P比值分别为5.6（0.1-52.3）和3.7（0.7-24.3）。OF和血浆浓度弱但显著相关（MDMA R2= 0.438，MDA R2= 0.197，p<0.0001）。高剂量后中位OF/P比值显著升高：MDMA低5.2（0.1-40.4）和高6.0（0.4-52.3）（p<0.05）; MDA低3.3（0.7-17.1）和高4.1（0.9-24.3）（p<0.001）。OF/P比值存在较大的受试者间差异。血浆中MDA/MDMA比值高于OF（p<0.001），且OF和血浆中MDA/MDMA比值随时间显著增加。MDMA和MDA浓度在OF高于血浆。OF和血浆浓度相关，但受试者间变异性较大，无法估计OF的血浆浓度。
Oral fluid (OF) offers a non-invasive sample collection for drug testing. However, 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) in OF has not been adequately characterized in comparison to plasma. We administered oral low (1.0 mg/kg) and high (1.6 mg/kg) dose MDMA to 26 participants and collected simultaneous OF and plasma specimens for up to 143 h after dosing. We compared OF/plasma (OF/P) ratios, time of initial detection (tfirst), maximal concentrations (Cmax), time of peak concentrations (tmax), time of last detection (tlast), clearance, and 3,4-methylenedioxyamphetamine (MDA) to MDMA ratios over time. For OF MDMA and MDA, Cmax was higher, tlast was later, and clearance was slower compared to plasma. For OF MDA only, tfirst was later compared to plasma. Median (range) OF/P ratios were 5.6 (0.1-52.3) for MDMA and 3.7 (0.7-24.3) for MDA. OF and plasma concentrations were weakly but significantly correlated (MDMA R2= 0.438, MDA R2= 0.197, p<0.0001). Median OF/P ratios were significantly higher following high dose: MDMA low 5.2 (0.1-40.4) and high 6.0 (0.4-52.3) (p<0.05); MDA low 3.3 (0.7-17.1) and high 4.1 (0.9-24.3) (p<0.001). There was large inter-subject variation in OF/P ratios. MDA/MDMA ratios in plasma were higher than those in OF (p<0.001), and MDA/MDMA ratios significantly increased over time in OF and plasma. MDMA and MDA concentrations were higher in OF than in plasma. OF and plasma concentrations were correlated, but large inter-subject variability precludes estimation of plasma concentrations from OF.
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DOI：
10.1111/j.1360-0443.2008.02277.x
发表时间：
2008-08
期刊：
Addiction (Abingdon, England)
影响因子：
--
作者：
Walsh JM;Verstraete AG;Huestis MA;Mørland J
通讯作者：
Mørland J
影响因子：
2.5
作者：
Kolbrich, Erin A.;Goodwin, Robert S.;Huestis, Marilyn A.
通讯作者：
Huestis, Marilyn A.
影响因子：
2.1
作者：
Samyn, N;van Haeren, C
通讯作者：
van Haeren, C
影响因子：
2.5
作者：
Barnes, Allan J.;Scheidweiler, Karl B.;Huestis, Marilyn A.
通讯作者：
Huestis, Marilyn A.
影响因子：
9.3
作者：
Peters, Frank T.;Samyn, Nele;Maurer, Hans H.
通讯作者：
Maurer, Hans H.