Zinc oxide nanoparticles for selective destruction of tumor cells and potential for drug delivery applications.
Zinc oxide nanoparticles for selective destruction of tumor cells and potential for drug delivery applications.
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DOI：
10.1517/17425247.2010.502560
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发表时间：
2010-09
影响因子：
6.6
通讯作者：
Wingett DG
中科院分区：
文献类型：
--
作者：
Rasmussen JW;Martinez E;Louka P;Wingett DG
包括氧化锌在内的金属氧化物纳米颗粒是生物医学应用和治疗干预的通用平台。迫切需要开发新的抗癌药物，最近的研究表明，ZnO纳米材料具有相当大的前景。这篇综述分析了在实验，临床前和临床水平上开发的金属氧化物和ZnO纳米材料的生物医学应用。讨论的优点，方法，和周围的金属氧化物纳米粒子用于癌症的应用和药物输送的限制。本文的范围主要集中在ZnO和其他金属氧化物纳米材料系统，以及它们提出的细胞毒性作用机制，以及目前改善其靶向和细胞毒性的方法。通过更好地了解纳米颗粒与细胞相互作用的作用机制和细胞后果，ZnO纳米颗粒对抗癌症的固有毒性和选择性可能会进一步提高，使其成为有吸引力的新型抗癌剂。
Metal oxide nanoparticles, including zinc oxide, are versatile platforms for biomedical applications and therapeutic intervention. There is an urgent need to develop new classes of anticancer agents, and recent studies demonstrate that ZnO nanomaterials hold considerable promise. This review analyzes the biomedical applications of metal oxide and ZnO nanomaterials under development at the experimental, preclinical, and clinical levels. A discussion regarding the advantages, approaches, and limitations surrounding the use of metal oxide nanoparticles for cancer applications and drug delivery is presented. The scope of this article is focused on ZnO, and other metal oxide nanomaterial systems, and their proposed mechanisms of cytotoxic action, as well as current approaches to improve their targeting and cytotoxicity against cancer cells. Through a better understanding of the mechanisms of action and cellular consequences resulting from nanoparticles interactions with cells, the inherent toxicity and selectivity of ZnO nanoparticles against cancer may be further improved to make them attractive new anti-cancer agents.
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影响因子：
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作者：
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发表时间：
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影响因子：
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