Reverse zoonosis of influenza to swine: new perspectives on the human-animal interface.

Reverse zoonosis of influenza to swine: new perspectives on the human-animal interface.
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DOI:
10.1016/j.tim.2014.12.002
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发表时间:
2015-03
影响因子:
15.9
通讯作者:
Vincent, Amy L.
Vincent, Amy L.
中科院分区:
生物学1区
文献类型:
--
作者:
Nelson, Martha I.;Vincent, Amy L.

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2009 年猪场甲型 H1N1 流感大流行的起源尚不清楚,这突显了我们对甲型流感病毒生态和进化的理解上的差距。在此,我们回顾一下最近加强的猪流感病毒监测显示,流感病毒从人到猪的传播比猪到人的人畜共患病要频繁得多,并且对于在全球范围内向猪传播新的病毒多样性至关重要。全球人传猪的规模代表了迄今为止记录到的最大规模的病原体“反向人畜共患病”。克服将猪视为人类病毒来源而不是接受者的偏见,是理解人与动物界面的双向性质如何对双方宿主产生流感威胁的关键。
The origins of the influenza A (H1N1) pandemic of 2009 in swine are unknown, highlighting gaps in our understanding of influenza A virus ecology and evolution. Here we review how recently strengthened influenza virus surveillance in pigs has revealed that influenza virus transmission from humans to swine is far more frequent than swine-to-human zoonosis, and is central in seeding swine globally with new viral diversity. The scale of global human-to-swine transmission represents the largest ‘reverse zoonosis’ of a pathogen documented to date. Overcoming the bias towards perceiving swine as sources of human viruses, rather than recipients, is key to understanding how the bidirectional nature of the human-animal interface produces influenza threats to both hosts.
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发表时间: 2012
期刊: mBio
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作者:
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