A statistical parametric mapping toolbox used for voxel-wise analysis of FDG-PET images of rat brain.
A statistical parametric mapping toolbox used for voxel-wise analysis of FDG-PET images of rat brain.
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用于对大鼠大脑 FDG-PET 图像进行体素分析的统计参数映射工具箱。
DOI：
10.1371/journal.pone.0108295
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Shan B
中科院分区：
文献类型：
--
作者：
Nie B;Liu H;Chen K;Jiang X;Shan B
利用氟代脱氧葡萄糖(18F-FDG)对动物脑功能代谢的正电子发射断层扫描(PET)成像研究在神经科学研究中具有重要意义。FDG-PET成像研究通常是在多组大鼠身上进行的，因此需要建立一种客观的基于体素的统计方法来进行组数据分析。建立了一个用于对大鼠脑FDG-PET图像进行体素分析的统计参数映射(SPM)工具箱(插件)spmratIHEP，在该工具箱中构建了FDG-PET模板和Paxinos&Watson空间的大鼠脑内掩模图像，并根据大鼠脑的特征修改了默认设置。与以前的研究相比，我们构建的大鼠大脑模板不仅包括大脑和小脑，还包括整个嗅球，这使得后来的认知研究更加详尽。利用模板空间中的颅内模板图像，可以自动提取出个体的脑组织。此外，地图集空间用于对Paxinos&Watson空间中的功能发现进行解剖学标记。为了准确地将模板图像与图谱进行标准化，从图谱构建了具有六个主要解剖结构的合成FDG-PET图像，作为联合配准中的目标图像。对空间归一化方法进行了评价，成功地将大鼠个体脑图像归一化到Paxinos&Watson空间，并准确地提取了脑组织。使用左侧大脑中动脉闭塞(MCAO)大鼠的FDG-PET功能图像与正常对照大鼠进行比较，评估该工具箱的实用性。两样本t检验统计结果与左侧大脑中动脉基本相关。我们建立了一个SPM8工具箱spmratIHEP，用于对大鼠大脑的FDG-PET图像进行体素分析。
PET (positron emission tomography) imaging researches of functional metabolism using fluorodeoxyglucose (18F-FDG) of animal brain are important in neuroscience studies. FDG-PET imaging studies are often performed on groups of rats, so it is desirable to establish an objective voxel-based statistical methodology for group data analysis. This study establishes a statistical parametric mapping (SPM) toolbox (plug-ins) named spmratIHEP for voxel-wise analysis of FDG-PET images of rat brain, in which an FDG-PET template and an intracranial mask image of rat brain in Paxinos & Watson space were constructed, and the default settings were modified according to features of rat brain. Compared to previous studies, our constructed rat brain template comprises not only the cerebrum and cerebellum, but also the whole olfactory bulb which made the later cognitive studies much more exhaustive. And with an intracranial mask image in the template space, the brain tissues of individuals could be extracted automatically. Moreover, an atlas space is used for anatomically labeling the functional findings in the Paxinos & Watson space. In order to standardize the template image with the atlas accurately, a synthetic FDG-PET image with six main anatomy structures is constructed from the atlas, which performs as a target image in the co-registration. The spatial normalization procedure is evaluated, by which the individual rat brain images could be standardized into the Paxinos & Watson space successfully and the intracranial tissues could also be extracted accurately. The practical usability of this toolbox is evaluated using FDG-PET functional images from rats with left side middle cerebral artery occlusion (MCAO) in comparison to normal control rats. And the two-sample t-test statistical result is almost related to the left side MCA. We established a toolbox of SPM8 named spmratIHEP for voxel-wise analysis of FDG-PET images of rat brain.
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影响因子：
4.8
作者：
Nie, Binbin;Chen, Kewei;Zhao, Shujun;Liu, Junhua;Gu, Xiaochun;Yao, Qunli;Hui, Jiaojie;Zhang, Zhijun;Teng, Gaojun;Zhao, Chunjie;Shan, Baoci
通讯作者：
Shan, Baoci
大鼠脑磁共振成像研究中追踪感兴趣区域的自动方法
影响因子：
4.4
作者：
Nie, Binbin;Hui, Jiaojie;Zhao, Shujun
通讯作者：
Zhao, Shujun
DOI：
10.1016/j.jalz.2010.03.003
发表时间：
2010-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Jagust WJ;Bandy D;Chen K;Foster NL;Landau SM;Mathis CA;Price JC;Reiman EM;Skovronsky D;Koeppe RA;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
影响因子：
6.3
作者：
Schubert, Carla R.;Carmichael, Lakeesha L.;Murphy, Claire;Klein, Barbara E. K.;Klein, Ronald;Cruickshanks, Karen J.
通讯作者：
Cruickshanks, Karen J.
影响因子：
5.7
作者：
Matsumura, A;Mizokawa, S;Watanabe, Y
通讯作者：
Watanabe, Y