Olfaction and the 5-year incidence of cognitive impairment in an epidemiological study of older adults.
Olfaction and the 5-year incidence of cognitive impairment in an epidemiological study of older adults.
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DOI：
10.1111/j.1532-5415.2008.01826.x
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发表时间：
2008-08
影响因子：
6.3
通讯作者：
Cruickshanks, Karen J.
中科院分区：
文献类型：
--
作者：
Schubert, Carla R.;Carmichael, Lakeesha L.;Murphy, Claire;Klein, Barbara E. K.;Klein, Ronald;Cruickshanks, Karen J.
为了确定气味识别能力是否与基线时认知正常的大量老年人的5年认知障碍发生率有关，以及嗅觉障碍是否有助于预测人群中的认知下降。基于人群的纵向研究。威斯康星州海狸大坝1920名听力损失流行病学研究参与者(平均年龄66.9岁)。嗅觉通过圣地亚哥气味识别测试(SDOIT)进行测量。事件认知障碍被定义为一项简易精神状态检查评分(≥24)或在随访时报告的痴呆症或阿尔茨海默病(AD)，且基线时未诊断出痴呆症或阿尔茨海默病。基线时的嗅觉损害与5年认知损害的发生率显著相关(优势比(OR)=6.62，95%可信区间(C.I.)=4.36，10.05)。在调整了可能的混杂因素后，相关性仍然显著(OR=3.72，95%CI=2.31，5.99)。SDOIT对5年认知功能损害的阳性预测值为15.9%，阴性预测值为97.2%，敏感度为55.1%，特异度为84.4%。根据MMSE的测量，基线时的嗅觉障碍与认知障碍的5年发生率密切相关。气味识别测试在高风险环境中可能有用，但在普通人群中却没有用，以确定认知能力下降的风险患者。
To determine if odor identification ability is associated with the 5-year incidence of cognitive impairment in a large population of older adults with normal cognition at baseline and if olfactory impairment contributes to the prediction of cognitive decline in a population. Population-based longitudinal study. Beaver Dam, WI. 1920 participants in the Epidemiology of Hearing Loss Study (mean age = 66.9 years). Olfaction was measured by the San Diego Odor Identification Test (SDOIT). Incident cognitive impairment was defined as a Mini-Mental State Exam Score (MMSE) < 24 or reported diagnosis of dementia or Alzheimer’s disease (AD) at the follow-up among people with MMSE ≥ 24 and no diagnosis of dementia or AD at baseline. There was a significant association between olfactory impairment at baseline and the 5-year incidence of cognitive impairment (Odds Ratio (O.R.) = 6.62, 95% Confidence Interval (C.I.) = 4.36, 10.05). The association remained significant after adjusting for possible confounders (O.R. = 3.72, 95% C.I. = 2.31, 5.99). The Positive Predictive Value of the SDOIT was 15.9%, the Negative Predictive Value was 97.2% and the sensitivity and specificity were 55.1% and 84.4%, respectively, for the 5-year incidence of cognitive impairment. Olfactory impairment at baseline was strongly associated with the 5-year incidence of cognitive impairment as measured by the MMSE. Odor identification testing may be useful in high risk settings, but not in the general population, to identify patients at risk for cognitive decline.
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影响因子：
120.7
作者：
Murphy, C;Schubert, CR;Nondahl, DM
通讯作者：
Nondahl, DM
影响因子：
--
作者：
Wilson, Robert S.;Schneider, Julie A.;Bennett, David A.
通讯作者：
Bennett, David A.
影响因子：
3
作者：
Murphy, C;Morgan, CD;Polich, JM
通讯作者：
Polich, JM
影响因子：
4.2
作者：
PRICE, JL;DAVIS, PB;WHITE, DL
通讯作者：
WHITE, DL
影响因子：
5.7
作者：
Swan, GE;Carmelli, D
通讯作者：
Carmelli, D