Modification of existing human motor memories is enabled by primary cortical processing during memory reactivation.
Modification of existing human motor memories is enabled by primary cortical processing during memory reactivation.
复制标题
DOI：
10.1016/j.cub.2010.07.047
复制
发表时间：
2010-09-14
期刊：
影响因子：
9.2
通讯作者：
Cohen, Leonardo G.
中科院分区：
文献类型：
--
作者：
Censor, Nitzan;Dimyan, Michael A.;Cohen, Leonardo G.
大脑最具挑战性的任务之一是不断更新现有记忆的内部神经表征。动物研究使用了侵入性方法，如将蛋白质抑制剂直接微融合到指定的大脑区域，以研究在回忆过程中重新激活已经存在的记忆后修改的神经机制。因为这种干预在人类身上是不可能的，所以我们不知道这些神经过程是如何在人脑中运作的。在一系列的实验中，我们发现，当现有的人类运动记忆在回忆过程中被重新激活时，对记忆的修改被相关的人类大脑初级皮层区域的虚拟损伤所阻止。虚拟病变是由无框架立体定向脑导航系统和每个受试者的脑图像引导的无创重复经颅磁刺激诱导的。结果表明，人类大脑皮层初级加工与预先存在的再激活记忆痕迹相互作用是成功修改现有相关记忆的关键。非侵入性皮层刺激对再激活记忆的调节可能对人类记忆研究具有重要意义，并具有深远的临床应用价值。
One of the most challenging tasks of the brain is to constantly update the internal neural representations of existing memories. Animal studies have used invasive methods such as direct microfusion of protein inhibitors to designated brain areas, in order to study the neural mechanisms underlying modification of already existing memories after their reactivation during recall. Because such interventions are not possible in humans, it is not known how these neural processes operate in the human brain. In a series of experiments we show here that when an existing human motor memory is reactivated during recall, modification of the memory is blocked by virtual lesion of the related primary cortical human brain area. The virtual lesion was induced by noninvasive repetitive transcranial magnetic stimulation guided by a frameless stereotactic brain navigation system and each subject’s brain image. The results demonstrate that primary cortical processing in the human brain interacting with pre-existing reactivated memory traces is critical for successful modification of the existing related memory. Modulation of reactivated memories by noninvasive cortical stimulation may have important implications for human memory research and have far-reaching clinical applications.
登录
查看更多内容
影响因子：
64.8
作者：
Nader, K;Schafe, GE;Le Doux, JE
通讯作者：
Le Doux, JE
影响因子：
25
作者：
Korman, Maria;Doyon, Julien;Karni, Avi
通讯作者：
Karni, Avi
影响因子：
3.2
作者：
Vangheluwe, S;Wenderoth, N;Swinnen, SP
通讯作者：
Swinnen, SP
影响因子：
16.2
作者：
Albouy, Genevieve;Sterpenich, Virginie;Maquet, Pierre
通讯作者：
Maquet, Pierre
影响因子：
64.8
作者：
Walker, MP;Brakefield, T;Stickgold, R
通讯作者：
Stickgold, R