Engineering peripheral nerve repair.

Engineering peripheral nerve repair.
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DOI:
10.1016/j.copbio.2013.05.006
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发表时间:
2013-10
影响因子:
7.7
通讯作者:
Sakiyama-Elbert, Shelly E.
Sakiyama-Elbert, Shelly E.
中科院分区:
工程技术1区
文献类型:
--
作者:
Marquardt, Laura M.;Sakiyama-Elbert, Shelly E.

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目前用于治疗周围神经损伤的方法已经产生了有希望的,但与临床护理标准、自体神经移植物相比功能恢复不足。为了设计一种可以匹配自体移植物再生潜力的结构,神经组织的所有方面都必须纳入组合治疗。未来的工程生物材料支架必须通过靶向再生神经对其周围微环境的高度敏感反应来促进增强的再生和适当的神经再支配。
Current approaches for treating peripheral nerve injury have resulted in promising, yet insufficient functional recovery compared to the clinical standard of care, autologous nerve grafts. In order to design a construct that can match the regenerative potential of the autograft, all facets of nerve tissue must be incorporated in a combinatorial therapy. Engineered biomaterial scaffolds in the future will have to promote enhanced regeneration and appropriate reinnervation by targeting the highly sensitive response of regenerating nerves to their surrounding microenvironment.
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