Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease.
Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease.
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DOI：
10.1080/10715760802644694
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发表时间：
2009-02
影响因子：
3.3
通讯作者：
Perry G
中科院分区：
文献类型：
--
作者：
Siedlak SL;Casadesus G;Webber KM;Pappolla MA;Atwood CS;Smith MA;Perry G
氧化修饰是阿尔茨海默病、帕金森病和朊病毒病患者及其各自动物模型大脑中氧化失衡的标志。虽然氧化应激的原因是相对有据可查的，但长期减少氧化应激对认知、病理学和生物化学的影响需要进一步澄清。为了解决这个问题，年轻和老年对照和淀粉样β蛋白受体过表达的小鼠被喂食添加有R-α硫辛酸的饮食10个月，以确定长期抗氧化剂给药对大脑的认知和神经病理学和生物化学的影响。用R-α硫辛酸处理的野生型和转基因小鼠均显示氧化修饰标记物显著减少。另一方面，R-α硫辛酸在整个研究中对Y-迷宫性能几乎没有影响，并且没有降低终点淀粉样蛋白-β负荷。这些结果表明，尽管氧化应激在衰老和Aβ PP转基因小鼠中介导淀粉样蛋白病理学和认知能力下降中具有明确的作用，但在可耐受的营养指南范围内的长期抗氧化剂治疗水平并减少氧化修饰的获益有限。
Oxidative modifications are a hallmark of oxidative imbalance in the brains of individuals with Alzheimer’s, Parkinson’s and prion diseases and their respective animal models. While the causes of oxidative stress are relatively well-documented, the effects of chronically reducing oxidative stress on cognition, pathology and biochemistry require further clarification. To address this, young and aged control and amyloid-β protein precursor-over-expressing mice were fed a diet with added R-alpha lipoic acid for 10 months to determine the effect of chronic antioxidant administration on the cognition and neuropathology and biochemistry of the brain. Both wild type and transgenic mice treated with R-alpha lipoic acid displayed significant reductions in markers of oxidative modifications. On the other hand, R-alpha lipoic acid had little effect on Y-maze performance throughout the study and did not decrease end-point amyloid-β load. These results suggest that, despite the clear role of oxidative stress in mediating amyloid pathology and cognitive decline in ageing and AβPP-transgenic mice, long-term antioxidant therapy, at levels within tolerable nutritional guidelines and which reduce oxidative modifications, have limited benefit.
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影响因子：
4.8
作者：
Chyan, YJ;Poeggeler, B;Pappolla, MA
通讯作者：
Pappolla, MA
影响因子：
4.2
作者：
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4.2
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2.4
作者：
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影响因子：
4.1
作者：
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通讯作者：
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