Conserved F-actin dynamics and force transmission at cell adhesions.
Conserved F-actin dynamics and force transmission at cell adhesions.
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DOI：
10.1016/j.ceb.2010.07.010
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发表时间：
2010-10
影响因子：
7.5
通讯作者：
Gardel, Margaret L.
中科院分区：
文献类型：
--
作者：
Maruthamuthu, Venkat;Aratyn-Schaus, Yvonne;Gardel, Margaret L.
Adhesions are a central mechanism by which cells mechanically interact with the surrounding extracellular matrix (ECM) and neighboring cells. In both cell-ECM and cell-cell adhesions, forces generated within the actin cytoskeleton are transmitted to the surrounding environment and are essential for numerous morphogenic processes. Despite differences in many molecular components that regulate cell-cell and cell-ECM adhesions, the roles of F-actin dynamics and mechanical forces in adhesion regulation are surprisingly similar. Moreover, force transmission at adhesions occurs concomitantly with dynamic F-actin; proteins comprising the adhesion of F-actin to the plasma membrane must accommodate this movement while still facilitating force transmission. Thus, despite different molecular architectures, integrin and cadherin-mediated adhesions operate with common biophysical characteristics to transmit and respond to mechanical forces in a multicellular tissue.
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