Amyloid beta peptides, locus coeruleus-norepinephrine system and dense core vesicles.
Amyloid beta peptides, locus coeruleus-norepinephrine system and dense core vesicles.
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DOI：
10.1016/j.brainres.2018.03.009
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发表时间：
2019-01-01
期刊：
影响因子：
2.9
通讯作者：
Van Bockstaele EJ
中科院分区：
文献类型：
--
作者：
Ross JA;Reyes BAS;Van Bockstaele EJ
中枢神经系统中肽能信号系统的进化在脑过程和功能中起着独特而关键的作用。生理肽的多样性和它们的调节和分泌的复杂性从致密的核心囊泡（DCV）在整个大脑是一个非常需要调查的话题，虽然近年来已经阐明了细胞和分子机制，总结在这篇评论。在这里，我们专注于收敛的肽能系统的蓝斑（LC），去甲肾上腺素（NE）的唯一供应商的皮层和海马，通过大DCV。由于LC-NE系统是阿尔茨海默病（AD）中最先发生变性的脑区域之一，并且DCV标志物已被一致证明具有AD进展的生物标志物潜力，因此我们总结了将LC-NE系统与DCV失调和Aβ肽联系起来的现有文献。我们还包括神经解剖学数据，表明老年斑的构建模块，Aβ单体，可能定位于LC的DCV和前额叶皮质的去甲肾上腺素能轴突终末。最后，我们探讨了慢性应激对Aβ产生的可能后果以及DCV在LC变性中可能发挥的作用。对AD患者DCV免疫学标志物的临床资料进行了讨论。
The evolution of peptidergic signaling systems in the central nervous system serves a distinct and crucial role in brain processes and function. The diversity of physiological peptides and the complexity of their regulation and secretion from the dense core vesicles (DCV) throughout the brain is a topic greatly in need of investigation, though recent years have shed light on cellular and molecular mechanisms that are summarized in this review. Here, we focus on the convergence of peptidergic systems onto the Locus Coeruleus (LC), the sole provider of norepinephrine (NE) to the cortex and hippocampus, via large DCV. As the LC-NE system is one of the first regions of the brain to undergo degeneration in Alzheimer’s Disease (AD), and markers of DCV have consistently been demonstrated to have biomarker potential for AD progression, here we summarize the current literature linking the LC-NE system with DCV dysregulation and Aβ peptides. We also include neuroanatomical data suggesting that the building blocks of senile plaques, Aβ monomers, may be localized to DCV of the LC and noradrenergic axon terminals of the prefrontal cortex. Finally, we explore the putative consequences of chronic stress on Aβ production and the role that DCV may play in LC degeneration. Clinical data of immunological markers of DCV in AD patients are discussed.
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影响因子：
3
作者：
CARMICHAEL, SW;WINKLER, H
通讯作者：
WINKLER, H
影响因子：
--
作者：
Davis, KL;Mohs, RC;Haroutunian, V
通讯作者：
Haroutunian, V
影响因子：
4.7
作者：
Feinstein, Douglas L.;Kalinin, Sergey;Braun, David
通讯作者：
Braun, David
影响因子：
2.5
作者：
Aston-Jones, G;Cohen, JD
通讯作者：
Cohen, JD
DOI：
10.1111/j.1749-6632.1987.tb27189.x
发表时间：
1987-04-24
影响因子：
5.2
作者：
FISCHERCOLBRIE, R;HAGN, C;SCHOBER, M
通讯作者：
SCHOBER, M