Broad frequency sensitivity and complex neural coding in the larval zebrafish auditory system.
Broad frequency sensitivity and complex neural coding in the larval zebrafish auditory system.
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DOI：
10.1016/j.cub.2021.01.103
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发表时间：
2021-05-10
期刊：
影响因子：
--
通讯作者：
Scott EK
中科院分区：
文献类型：
--
作者：
Poulsen RE;Scholz LA;Constantin L;Favre-Bulle I;Vanwalleghem GC;Scott EK
大多数动物都有复杂的听觉系统，可以识别声音景观的显著特征，以指导适当的反应。在鱼类中，这些特征包括通过水传播的声刺激的体积、频率、复杂性和时间结构。与成年鱼相比，幼鱼的大脑简单，但游动自由，依靠复杂的感官处理来生存。斑马鱼幼体是研究全脑神经网络的重要模型，迄今为止，人们发现斑马鱼幼体具有基本的听觉系统，对狭窄的频率范围敏感，对声学特征没有明显的敏感性，而声学特征对成年鱼来说是显著的和行为学上重要的。在这里，我们结合了一种传递水生声音的新方法，一种不同的声刺激组合，以及全脑钙成像来描述斑马鱼幼虫大脑中单个听觉反应神经元的反应。我们的研究结果揭示了对100Hz到4kHz频率范围的响应，以及100Hz到2.5kHz频率区分的证据。频率选择神经元分布在大脑的许多区域，对相同频率作出反应的神经元在空间上分组在某些区域。使用功能聚类，我们已经确定了神经元的类别，这些神经元对单一频率的纯音、白噪声、突然出现的声刺激和涉及逐渐增强的刺激有选择性。这些结果表明，幼鱼的听觉系统比以前所描述的更微妙，并为幼鱼的听觉系统如何能够敏锐地发挥作用并作为更复杂的成年系统的支架提供了见解。
Most animals have complex auditory systems that identify salient features of the acoustic landscape to direct appropriate responses. In fish, these features include the volume, frequency, complexity, and temporal structure of acoustic stimuli transmitted through water. Larval fish have simple brains compared to adults, but swim freely and depend on sophisticated sensory processing for survival. Zebrafish larvae, an important model for studying brain-wide neural networks, have thus far been found to possess a rudimentary auditory system, sensitive to a narrow range of frequencies and without evident sensitivity to acoustic features that are salient and ethologically important to adult fish. Here, we have combined a novel method for delivering water-borne sounds, a diverse assembly of acoustic stimuli, and whole-brain calcium imaging to describe the responses of individual auditory-responsive neurons across the brains of zebrafish larvae. Our results reveal responses to frequencies ranging from 100Hz to 4kHz, with evidence of frequency discrimination from 100Hz to 2.5kHz. Frequency-selective neurons are located in numerous regions of the brain, and neurons responsive to the same frequency are spatially grouped in some regions. Using functional clustering, we have identified categories of neurons that are selective for pure tones of a single frequency, white noise, the sharp onset of acoustic stimuli, and stimuli involving a gradual crescendo. These results suggest a more nuanced auditory system than has previously been described in larval fish and provide insights into how a young animal’s auditory system can both function acutely and serve as the scaffold for a more complex adult system.
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影响因子：
9.2
作者：
Ehrlich, David E.;Schoppik, David
通讯作者：
Schoppik, David
DOI：
10.1007/bf01326837
发表时间：
1981-01-01
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY
影响因子：
--
作者：
EATON, RC;LAVENDER, WA;WIELAND, CM
通讯作者：
WIELAND, CM
影响因子：
5.3
作者：
Burgess, Harold A.;Granato, Michael
通讯作者：
Granato, Michael
影响因子：
3
作者：
Bang, PI;Yelick, PC;Sewell, WF
通讯作者：
Sewell, WF
DOI：
10.1523/jneurosci.0065-12.2012
发表时间：
2012-07-04
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Guo W;Chambers AR;Darrow KN;Hancock KE;Shinn-Cunningham BG;Polley DB
通讯作者：
Polley DB