Ten-year change in sedentary behaviour, moderate-to-vigorous physical activity, cardiorespiratory fitness and cardiometabolic risk: independent associations and mediation analysis.
Ten-year change in sedentary behaviour, moderate-to-vigorous physical activity, cardiorespiratory fitness and cardiometabolic risk: independent associations and mediation analysis.
复制标题
久坐行为的十年变化，中度到剧烈的体育锻炼，心肺适应性和心脏代谢风险：独立关联和调解分析。
DOI：
10.1136/bjsports-2016-096083
复制
发表时间：
2018-08
影响因子：
18.4
通讯作者：
Wijndaele K
中科院分区：
文献类型：
--
作者：
Knaeps S;Bourgois JG;Charlier R;Mertens E;Lefevre J;Wijndaele K
我们的目的是研究久坐行为 (SB)、中度至剧烈体力活动 (MVPA) 和客观测量的心肺健康 (CRF) 的 10 年变化之间的独立关联，以及集群心脏代谢风险及其各个组成部分（腰围、空腹血糖、高密度脂蛋白 (HDL) 胆固醇、甘油三酯和血压）的同时变化。我们还确定了相关性是否由 CRF（对于 SB 和 MVPA）、腰围（对于 SB、MVPA 和 CRF）和饮食摄入量（对于 SB）的变化介导。对 425 名成年人（年龄（平均值±标准差）55.83±9.40；65% 男性）进行了为期 9.62±0.52 年的前瞻性随访。参与者自我报告 SB 和 MVPA，并进行最大自行车测功机测试，以估计基线（2002-2004 年）和随访（2012-2014 年）时的峰值摄氧量。多元线性回归和系数乘积法分别用于检验独立关联和中介效应。 SB 的更大增加与聚集心脏代谢风险、腰围、HDL 胆固醇和甘油三酯的更有害的变化相关，与 MVPA 的变化无关。 MVPA 的大幅下降与 HDL 胆固醇的大幅下降以及集群心脏代谢风险、腰围和空腹血糖的增加相关，与 SB 的变化无关。 CRF 的更大下降与集群心脏代谢风险和所有个体成分的更有害的变化相关。 CRF 的变化介导了 SB 和 MVPA 的变化与集群心脏代谢风险、腰围以及仅 MVPA 和 HDL 胆固醇变化的关联。腰围的变化介导了 CRF 变化与聚集心脏代谢风险、空腹血糖、HDL 胆固醇和甘油三酯变化之间的关联。减少 SB 和增加 MVPA 相结合，导致 CRF 发生积极变化，可能对心脏代谢健康最有利。
We aimed to study the independent associations of 10-year change in sedentary behaviour (SB), moderate-to-vigorous physical activity (MVPA) and objectively measured cardiorespiratory fitness (CRF), with concurrent change in clustered cardiometabolic risk and its individual components (waist circumference, fasting glucose, high-density lipoprotein (HDL) cholesterol, triglycerides and blood pressure). We also determined whether associations were mediated by change in CRF (for SB and MVPA), waist circumference (for SB, MVPA and CRF) and dietary intake (for SB). A population-based sample of 425 adults (age (mean±SD) 55.83±9.40; 65% men) was followed prospectively for 9.62±0.52 years. Participants self-reported SB and MVPA and performed a maximal cycle ergometer test to estimate peak oxygen uptake at baseline (2002–2004) and follow-up (2012–2014). Multiple linear regression and the product of coefficients method were used to examine independent associations and mediation effects, respectively. Greater increase in SB was associated with more detrimental change in clustered cardiometabolic risk, waist circumference, HDL cholesterol and triglycerides, independently of change in MVPA. Greater decrease in MVPA was associated with greater decrease in HDL cholesterol and increase in clustered cardiometabolic risk, waist circumference and fasting glucose, independent of change in SB. Greater decrease in CRF was associated with more detrimental change in clustered cardiometabolic risk and all individual components. Change in CRF mediated the associations of change in SB and MVPA with change in clustered cardiometabolic risk, waist circumference and, only for MVPA, HDL cholesterol. Change in waist circumference mediated the associations between change in CRF and change in clustered cardiometabolic risk, fasting glucose, HDL cholesterol and triglycerides. A combination of decreasing SB and increasing MVPA, resulting in positive change in CRF, is likely to be most beneficial towards cardiometabolic health.
登录
查看更多内容
血液甘油三酯对心血管和全因死亡率的影响：对 61 项前瞻性研究的系统回顾和荟萃分析
影响因子：
4.5
作者：
Liu J;Zeng FF;Liu ZM;Zhang CX;Ling WH;Chen YM
通讯作者：
Chen YM
影响因子：
16.2
作者：
Ford, ES
通讯作者：
Ford, ES
影响因子：
2.3
作者：
Foster, JA;Gore, SA;West, DS
通讯作者：
West, DS
影响因子：
39.3
作者：
Healy, Genevieve N.;Matthews, Charles E.;Owen, Neville
通讯作者：
Owen, Neville
DOI：
10.1186/1479-5868-9-76
发表时间：
2012-06-19
期刊：
The international journal of behavioral nutrition and physical activity
影响因子：
--
作者：
Chau JY;Merom D;Grunseit A;Rissel C;Bauman AE;van der Ploeg HP
通讯作者：
van der Ploeg HP