A systematic review on silver nanoparticles-induced cytotoxicity: Physicochemical properties and perspectives.
A systematic review on silver nanoparticles-induced cytotoxicity: Physicochemical properties and perspectives.
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DOI：
10.1016/j.jare.2017.10.008
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发表时间：
2018-01
影响因子：
10.7
通讯作者：
Kurasaki M
中科院分区：
文献类型：
--
作者：
Akter M;Sikder MT;Rahman MM;Ullah AKMA;Hossain KFB;Banik S;Hosokawa T;Saito T;Kurasaki M
随着纳米技术的发展，银纳米粒子(Ag-NPs)因其在各个领域的指数级应用而成为需求最大的纳米粒子之一。增加银纳米颗粒增强产品的使用可能会导致影响环境和生物的毒性水平增加。一些研究已经使用不同的模型细胞系来展示银纳米颗粒的细胞毒性及其潜在的分子机制。该综述旨在阐明导致细胞毒性的银纳米颗粒的不同性质，以及在体外观察到的关键作用机制和随后的防御机制。结果表明，不同的合成工艺对纳米银的性质有很大的影响。Ag-NPs的物理化学性质(如大小、形状、浓度、聚集或与生物系统的聚集相互作用)会在它们穿透和积聚在线粒体膜之前导致线粒体功能的损害。因此，银纳米粒子的性能在其作为杀菌剂的使用以及在环境清洁中的适用性方面发挥着核心作用。在此，我们报告了关于银纳米颗粒的合成、适用性和毒性的详细特征的最新综述。
With the development of nanotechnology, silver nanoparticles (Ag-NPs) have become one of the most in-demand nanoparticles owing to their exponential number of uses in various sectors. The increased use of Ag-NPs-enhanced products may result in an increased level of toxicity affecting both the environment and living organisms. Several studies have used different model cell lines to exhibit the cytotoxicity of Ag-NPs, and their underlying molecular mechanisms. This review aimed to elucidate different properties of Ag-NPs that are responsible for the induction of cellular toxicity along with the critical mechanism of action and subsequent defense mechanisms observed in vitro. Our results show that the properties of Ag-NPs largely vary based on the diversified synthesis processes. The physiochemical properties of Ag-NPs (e.g., size, shape, concentration, agglomeration, or aggregation interaction with a biological system) can cause impairment of mitochondrial function prior to their penetration and accumulation in the mitochondrial membrane. Thus, Ag-NPs exhibit properties that play a central role in their use as biocides along with their applicability in environmental cleaning. We herein report a current review of the synthesis, applicability, and toxicity of Ag-NPs in relation to their detailed characteristics.
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影响因子：
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