In-utero cannabis exposure and long-term psychiatric and neurodevelopmental outcomes: The limitations of existing literature and recommendations for future research.
In-utero cannabis exposure and long-term psychiatric and neurodevelopmental outcomes: The limitations of existing literature and recommendations for future research.
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DOI：
10.1002/bdr2.2060
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发表时间：
2022-08-01
影响因子：
2.1
通讯作者：
Avalos, Lyndsay A.
中科院分区：
文献类型：
--
作者：
Sujan, Ayesha C.;Young-Wolff, Kelly C.;Avalos, Lyndsay A.
鉴于妊娠期大麻使用的增加以及动物模型研究显示子宫内接触大麻的影响，需要关于子宫内接触大麻对人类的长期影响的高质量信息。虽然综述总结了人类观察性研究的结果，但综述并没有关注这些研究的局限性和对未来研究的建议。因此，我们严格审查了关于子宫内大麻暴露以及3岁或3岁后测量的精神和神经发育结果的观察性研究，并为未来的研究提供了建议。我们使用Web of Science、Google Scholar和相关已识别出版物中引用的工作，确定了46篇论文纳入我们的综述。我们的审查包括两个主要部分。第一部分强调了现有研究的广泛局限性，包括小样本和不可推广的样本，依赖自我报告的数据，缺乏暴露时间和暴露量的详细信息，仅纳入较早的暴露数据，不考虑重要的混杂因素，纳入潜在的介质作为协变量，不包括结局严重程度指标，不评估后代性别差异。第二部分为未来的研究提供了关于暴露和结果测量、样本选择、混杂因素调整和其他方法学考虑的建议。例如，关于接触定义，我们建议研究量化大麻接触量，评估接触时间的影响，并纳入生物措施（例如，尿液毒理学测量）。鉴于关于人类宫内接触大麻的长期后果的高质量信息尚未存在，未来的研究必须解决我们已经确定的局限性。
Given increases in cannabis use in pregnancy and animal model research showing effects of in-utero cannabis exposure, high-quality information on long-term consequences of in-utero cannabis exposure in humans is needed. While reviews have summarized findings from observational studies with humans, reviews have not focused on limitations of these studies and recommendations for future research. Therefore, we critically reviewed observational research on in-utero cannabis exposure and psychiatric and neurodevelopmental outcomes measured at or after age 3 and provided recommendations for future research. We used Web of Science, Google Scholar, and work cited from relevant identified publications to identify 46 papers to include in our review. Our review includes two main sections. The first section highlights the extensive limitations of the existing research, which include small and non-generalizable samples, reliance on self-reported data, lack of detail on timing and amount of exposure, inclusion of older exposure data only, not accounting for important confounders, inclusion of potential mediators as covariates, not including outcome severity measures, and not assessing for offspring sex differences. The second section provides recommendations for future research regarding exposure and outcome measures, sample selection, confounder adjustment, and other methodological considerations. For example, with regard to exposure definition, we recommend that studies quantify the amount of cannabis exposure, evaluate the influence of timing of exposure, and incorporate biological measures (e.g., urine toxicology measures). Given that high-quality information on long-term consequences of in-utero cannabis exposure in humans does not yet exit, it is crucial for future research to address the limitations we have identified.
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影响因子：
5.5
作者：
Auger, Nathalie;Rheaume, Marc-Andre;Thuy Mai Luu
通讯作者：
Thuy Mai Luu
DOI：
10.1111/j.1530-0277.1994.tb00041.x
发表时间：
1994-08-01
影响因子：
3.2
作者：
DAY, NL;RICHARDSON, GA;ROBLES, N
通讯作者：
ROBLES, N
影响因子：
4
作者：
Bendersky, M;Lewis, M
通讯作者：
Lewis, M
影响因子：
4.4
作者：
De Genna NM;Goldschmidt L;Richardson GA;Cornelius MD;Day NL
通讯作者：
Day NL
DOI：
10.1001/archpedi.1995.02170140027004
发表时间：
1995-02-01
影响因子：
--
作者：
DAHL, RE;SCHER, MS;DAY, N
通讯作者：
DAY, N