Centenarians--a useful model for healthy aging? A 29-year follow-up of hospitalizations among 40,000 Danes born in 1905.
Centenarians--a useful model for healthy aging? A 29-year follow-up of hospitalizations among 40,000 Danes born in 1905.
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DOI：
10.1111/j.1474-9726.2009.00474.x
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发表时间：
2009-06
期刊：
影响因子：
7.8
通讯作者：
Christensen K
中科院分区：
文献类型：
--
作者：
Engberg H;Oksuzyan A;Jeune B;Vaupel JW;Christensen K
百岁老人比目前的人类预期寿命多出约20-25岁。然而，百岁老人是否代表着健康老龄化仍然是一个悬而未决的问题。以前的研究受到一些方法学缺陷的阻碍，例如横断面设计和缺乏适当的对照组。在一项基于人群的纵向队列中，研究人员检验了百岁老人的表型是否可以作为健康老龄化的有用模型。这项研究是基于1977年1月1日通过丹麦民事登记系统(DCRS)确定的对丹麦1905年出生队列中活着的39945人的完整跟踪调查。使用的数据来自丹麦人口数据库和丹麦国家患者登记册(自1977年以来一直存在)。从1977年到2004年，对1905年的队列进行了住院和住院天数方面的跟踪调查。存活状态在2006年12月之前有效。从1977年到2004年，1905年的丹麦百岁老人在同一时间点上住院的时间大大少于他们寿命较短的同龄人。例如，在71-74岁，未住院的百岁老人比例为80.5%，而在80岁出头死亡的人中，这一比例为68.4%。这一趋势在两性中都很明显。由于与死亡年龄较小的同龄人相比，丹麦百岁老人的住院率和住院时间较低，因此丹麦百岁老人代表着健康的老年人。百岁老人构成了一个有用的研究群体，用于寻找与特殊长寿相关的固定特征，如基因。
Centenarians surpass the current human life expectancy with about 20–25 years. However, whether centenarians represent healthy aging still remains an open question. Previous studies have been hampered by a number of methodological shortcomings such as a cross-sectional design and lack of an appropriate control group. In a longitudinal population-based cohort, it was examined whether the centenarian phenotype may be a useful model for healthy aging. The study was based on a complete follow up of 39 945 individuals alive in the Danish 1905 birth cohort on January 1, 1977 identified through the Danish Civil Registration System (DCRS). Data from the Danish Demographic Database and The Danish National Patient Register (in existence since 1977) were used. The 1905 cohort was followed up from 1977 through 2004 with respect to hospitalizations and number of hospital days. Survival status was available until December 2006. Danish centenarians from the 1905 cohort were hospitalized substantially less than their shorter-lived contemporaries at the same point in time during the years 1977 through 2004. For example, at age 71–74, the proportion of nonhospitalized centenarians was 80.5% compared with 68.4% among individuals who died in their early 80s. This trend was evident in both sexes. As a result of their lower hospitalization rates and length of stay in hospital compared with their contemporaries, who died at younger ages, Danish centenarians represent healthy agers. Centenarians constitute a useful study population in the search for fixed traits associated with exceptional longevity, such as genotype.
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影响因子：
4
作者：
Darviri, Christina;Demakakos, Panayotes;Chliaoutakis, Joannnes
通讯作者：
Chliaoutakis, Joannnes
DOI：
10.1097/01.jgp.0000192501.03069.bc
发表时间：
2006-01-01
影响因子：
7.2
作者：
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通讯作者：
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影响因子：
6.7
作者：
Andersen-Ranberg, K;Christensen, K;Vaupel, JW
通讯作者：
Vaupel, JW
影响因子：
7
作者：
Beregi, E;Klinger, A
通讯作者：
Klinger, A
DOI：
10.1093/gerona/59.11.1195
发表时间：
2004-11-01
影响因子：
5.1
作者：
Bernstein, AM;Willcox, BJ;Perls, TT
通讯作者：
Perls, TT