Platelet Carcinoembryonic Antigen Cell Adhesion Molecule 5 (CEACAM5) as a Possible Novel Diagnostic Tool for Evaluation of Acute Coronary Syndrome
Platelet Carcinoembryonic Antigen Cell Adhesion Molecule 5 (CEACAM5) as a Possible Novel Diagnostic Tool for Evaluation of Acute Coronary Syndrome
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血小板癌胚抗原细胞粘附分子 5 (CEACAM5) 作为评估急性冠状动脉综合征的可能的新型诊断工具
DOI：
10.12659/msm.918913
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发表时间：
2019-12
期刊：
影响因子：
--
通讯作者：
Zhaohui Meng
中科院分区：
文献类型：
--
作者：
Wen Wan;Yujia Ye;Huawei Wang;Longjun Li;Yajuan Gu;Lai Yang;Lihong Yang;Han Liu;Chao Meng;Deng Li;Zhe Wang;Zhaohui Meng
急性冠状动脉综合征（ACS）大约每40秒发生一次，是每7例死亡中就有1例死亡的潜在原因。需要更准确的指标来区分ACS患者与心电图（ECG）和心肌酶阴性变化的患者。本研究旨在探讨血小板癌胚抗原细胞粘附分子-5（CEACAM 5/CEA/CD 66 e）的表达是否有助于预测ACS。材料/方法我们招募了82名参与者（平均年龄60岁，33名女性和49名男性）。使用双色流式细胞术评估洗涤的人血小板上CEA的表达。采用流式细胞术和Luminex多功能分析仪分别检测82例患者血小板和血清CEA水平。结果人血小板表面表达CEA。ACS患者血小板CEA表达显著高于冠状动脉正常者（P<0.01），而血清CEA表达无显著性差异（P=0.30）。血小板CEA水平升高可作为ACS的一个新的独立指标（P=0.0003）。血小板CEA检测（P=0.000002）和心肌肌钙蛋白I（cTnI）检测（P=0.0005）对ACS的诊断具有较高的敏感性和特异性，联合cTnI检测（P<0.0001）可提高诊断价值。结论ACS患者血小板CEA表达增高。因此，血小板CEA可能是ACS的一个新的和可靠的生物标志物。需要大规模的研究来证实这一假设。
Background Acute coronary syndrome (ACS) occurs approximately every 40 seconds, and was an underlying cause of death in 1 out of every 7 deaths. More accurate indicators are needed to distinguish patients with ACS from patients manifesting negative changes in electrocardiogram (ECG) and myocardial enzymes. This study aimed to investigate whether the expression of platelet carcinoembryonic antigen cell adhesion molecule-5 (CEACAM5/CEA/CD66e) could help predict ACS. Material/Methods We enrolled 82 participants (mean age 60 years, 33 females and 49 males). The expression of CEA on washed human platelets was assessed using two-color flow cytometry. The CEA levels on platelets and in serum of these 82 consecutive patients were detected using two-color whole-blood flow cytometry analysis and a custom-made Luminex multiplex assay, respectively. Results CEA was expressed on the surface of human platelets. The expression of platelet CEA (P<0.01), but not serum CEA (P=0.30), was significantly higher in patients with ACS compared to patients with normal coronary artery. Increased platelet CEA levels could serve as a new independent indicator for ACS (P=0.0003). Platelet CEA testing (P=0.000002), as well as cardiac troponin I (cTnI) (P=0.0005), can diagnose ACS with high sensitivity and specificity, and, combined with cTnI (P<0.0001), can improve the diagnostic value. Conclusions Platelet CEA expression was higher in individuals presenting with ACS. Hence, platelet CEA might be a novel and reliable biomarker for ACS. Large-scale studies are needed to confirm this hypothesis.
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影响因子：
37.8
作者：
Scanlon, PJ;Faxon, DP;Smith, SC
通讯作者：
Smith, SC
DOI：
10.1016/s1357-2725(02)00280-7
发表时间：
2003-08-01
影响因子：
4
作者：
Andrews, RK;Gardiner, EE;Berndt, MC
通讯作者：
Berndt, MC
急性冠状动脉综合征
DOI：
10.1201/9780429025396
发表时间：
2020
期刊：
Heart, lung & circulation
影响因子：
--
作者：
S. Honda;Y. Asaumi;M. Fujino;T. Yamane;R. Kumasaka;T. Nagai;Taichi Adachi;Tadayoshi Miyagi;T. Arakawa;M. Nakanishi;H. Sakamoto;J. Kotani;T. Noguchi;Y. Goto;T. Anzai;W. Shimizu;M. Ishihara
通讯作者：
M. Ishihara
DOI：
10.1016/j.cca.2018.05.009
发表时间：
2018-09
期刊：
Clinica chimica acta; international journal of clinical chemistry
影响因子：
--
作者：
Ying-hao Wen;Ding-Ping Chen
通讯作者：
Ying-hao Wen;Ding-Ping Chen
影响因子：
1.9
作者：
Anthony Hilliard;S. Kopecky
通讯作者：
Anthony Hilliard;S. Kopecky