Effects of resveratrol on bone health in type 2 diabetic patients. A double-blind randomized-controlled trial.
Effects of resveratrol on bone health in type 2 diabetic patients. A double-blind randomized-controlled trial.
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DOI：
10.1038/s41387-018-0059-4
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发表时间：
2018-09-20
影响因子：
6.1
通讯作者：
Procopio M
中科院分区：
文献类型：
--
作者：
Bo S;Gambino R;Ponzo V;Cioffi I;Goitre I;Evangelista A;Ciccone G;Cassader M;Procopio M
2型糖尿病（T2 DM）患者骨折风险增加。白藜芦醇在少数研究中显示出对骨骼健康的有益作用。本试验的目的是研究白藜芦醇对2型糖尿病患者骨密度（BMD）和钙代谢生物标志物的影响。在这项双盲随机安慰剂对照试验中，192名T2 DM门诊患者随机接受白藜芦醇500 mg/天（Resv 500组），白藜芦醇40 mg/天（Resv 40组）或安慰剂治疗6个月。在基线和6个月后测量BMD、骨矿物质含量（BMC）、血清钙、磷、碱性磷酸酶和25-羟基维生素D。在随访中，所有患者的钙浓度都增加了，而碱性磷酸酶的组内变化在两个白藜芦醇组中更高，25-羟基维生素D仅在Resv 500组中增加，组间无差异。安慰剂组的全身BMD显著降低，而安慰剂组和Resv 40组的全身BMC均降低。Resv 500组的BMD和BMC值未发生显著变化。Resv 500组与安慰剂组相比，全身BMD较基线变化的校正平均差异存在显著差异（0.01 vs −0.03 g/cm 2，p = 0.001）、全身BMC（4.04 vs −58.8 g，p < 0.001）、全身T评分（0.15 vs −0.26）和血清磷（0.07 vs −0.01 µmol/L，p = 0.002）。在亚组分析中，在Resv 500治疗的患者中，钙和25-羟基维生素D值较低的患者和饮酒者的BMD值增加到较高水平。补充500 mg白藜芦醇可预防2型糖尿病患者的骨密度丢失，特别是那些基线条件不利的患者。
Patients with type 2 diabetes (T2DM) are at increased fracture risk. Resveratrol has shown beneficial effects on bone health in few studies. The aim of this trial was to investigate the effects of resveratrol on bone mineral density (BMD) and on calcium metabolism biomarkers in T2DM patients. In this double-blind randomized placebo-controlled trial 192 T2DM outpatients were randomized to receive resveratrol 500 mg/day (Resv500 arm), resveratrol 40 mg/day (Resv40 arm) or placebo for 6 months. BMD, bone mineral content (BMC), serum calcium, phosphorus, alkaline phosphatase, and 25-hydroxy vitamin D were measured at baseline and after 6 months. At follow-up, calcium concentrations increased in all patients, while within-group variations in alkaline phosphatase were higher in both resveratrol arms, and 25-hydroxy vitamin D increased in the Resv500 arm only, without between-group differences. Whole-body BMD significantly decreased in the placebo group, while whole-body BMC decreased in both the placebo and Resv40 arms. No significant changes in BMD and BMC values occurred in the Resv500 arm. The adjusted mean differences of change from baseline were significantly different in the Resv500 arm vs placebo for whole-body BMD (0.01 vs −0.03 g/cm2, p = 0.001), whole-body BMC (4.04 vs −58.8 g, p < 0.001), whole-body T-score (0.15 vs −0.26), and serum phosphorus (0.07 vs −0.01 µmol/L, p = 0.002). In subgroup analyses, in Resv500 treated-patients BMD values increased to higher levels in those with lower calcium and 25-hydroxy vitamin D values, and in alcohol drinkers. Supplementation with 500 mg resveratrol prevented bone density loss in patients with T2DM, in particular, in those with unfavorable conditions at baseline.
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影响因子：
2.8
作者：
Cooley J;Broderick TL;Al-Nakkash L;Plochocki JH
通讯作者：
Plochocki JH
影响因子：
5.9
作者：
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通讯作者：
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DOI：
10.1016/j.amjmed.2011.06.013
发表时间：
2011-11
期刊：
The American journal of medicine
影响因子：
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影响因子：
5.6
作者：
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影响因子：
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作者：
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通讯作者：
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