Circular RNAs: An emerging type of RNA in cancer.
Circular RNAs: An emerging type of RNA in cancer.
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DOI：
10.1177/0394632016686985
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发表时间：
2017-03
影响因子：
3.5
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Hou LD;Zhang J
环状RNA（Circular RNA，circRNA）是一类分布广泛、多样的新型内源性非编码RNA（non-coding RNA，ncRNA），与线性RNA不同，它形成共价闭合的连续环，没有5'或3'极性。大多数circRNA在不同物种中是丰富的、保守的和稳定的，并且表现出组织/发育阶段特异性特征。它们主要通过一种称为“反向剪接”的RNA剪接产生，其中下游剪接供体通过剪接跳跃或直接剪接连接到上游剪接受体。近年来的研究发现，circRNA具有microRNA海绵的功能，与RNA相关蛋白结合形成RNA-蛋白复合物，进而调控基因转录和翻译成多肽。新的证据表明，circRNA在多种癌症的发生和发展中起着重要的调节作用，作为潜在的诊断和预测生物标志物参与肿瘤的生长和侵袭，并为癌症诊断和靶向治疗提供新的策略。在这篇综述中，我们简要描述了circRNA的多样性和特征，并讨论了circRNA生物起源的亮点及其在肿瘤中的潜在功能。
Circular RNAs (circRNAs), a novel type of widespread and diverse endogenous non-coding RNAs (ncRNAs), which are different from the linear RNAs, form a covalently closed continuous loop without 5’ or 3’ polarities. The majority of circRNAs are abundant, conserved and stable across different species, and exhibit tissue/developmental-stage-specific characteristics. They are generated primarily through a type of alternative RNA splicing called “back-splicing,” in which a downstream splice donor is joined to an upstream splice acceptor through splice skipping or direct splice. Recent studies have discovered circRNAs function as microRNA sponges, binding with RNA-associated proteins to form RNA–protein complexes and then regulating gene transcription and translation into polypeptides. Emerging evidence indicates that circRNAs play important roles in the regulation of the development and progression of multiple cancers by serving as potential diagnostic and predictive biomarkers involved in tumor growth and invasion and providing new strategies for cancer diagnosis and targeted therapy. In this review, we briefly delineate the diversity and characteristics of circRNAs and discuss the highlights of the biogenesis of circRNAs and their potential functions in tumor.
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影响因子：
4.5
作者：
Burd CE;Jeck WR;Liu Y;Sanoff HK;Wang Z;Sharpless NE
通讯作者：
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通讯作者：
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影响因子：
4.1
作者：
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通讯作者：
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4.1
作者：
Dudekulay, Dawood B.;Panda, Amaresh C.;Gorospe, Myriam
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Gorospe, Myriam