Methylmercury exposure and adverse cardiovascular effects in Faroese whaling men.
Methylmercury exposure and adverse cardiovascular effects in Faroese whaling men.
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DOI：
10.1289/ehp.11608
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发表时间：
2009-03
影响因子：
10.4
通讯作者：
Grandjean P
中科院分区：
文献类型：
--
作者：
Choi AL;Weihe P;Budtz-Jørgensen E;Jørgensen PJ;Salonen JT;Tuomainen TP;Murata K;Nielsen HP;Petersen MS;Askham J;Grandjean P
甲基汞(MeHg)是一种在鱼类和海鲜中发现的世界性污染物，它与心血管死亡风险的增加有关。我们检查了42名法罗群岛捕鲸人(30-70岁)，以评估食用领航鲸肉类在广泛的甲基汞暴露范围内可能产生的不良影响。我们通过对脚趾甲和全血的汞分析(在临床检查时获得)和7年前收集的头发样本来评估暴露水平。观察指标包括心率变异性(HRV)、血压(BP)、颈总动脉内中膜厚度(IMT)和脑干听觉诱发电位(BAEP)。我们进行了多元回归和结构方程模型分析，以确定汞暴露的混杂调节效应。考虑到相关测量之间的相关性，我们对暴露和结果进行了分组，以得出中小企业的潜在暴露和反应变量。我们使用多元回归分析来比较个体暴露生物标志物和潜在暴露变量对个体和潜在结果的预测有效性。趾甲汞浓度变化很大，几何平均值为2.0μg/g；毛发浓度平均高出约3倍。汞暴露与血压和IMT增加显著相关。这种影响反映在扫描电子显微镜上，但脚趾甲中的汞往往是最好的效果预测因子。这一结果支持了增加甲基汞暴露促进心血管疾病发展的观点。
Methylmercury (MeHg), a worldwide contaminant found in fish and seafood, has been linked to an increased risk of cardiovascular mortality. We examined 42 Faroese whaling men (30–70 years of age) to assess possible adverse effects within a wide range of MeHg exposures from consumption of pilot whale meat. We assessed exposure levels from mercury analysis of toenails and whole blood (obtained at the time of clinical examination), and a hair sample collected 7 years previously. Outcome measures included heart rate variability (HRV), blood pressure (BP), common carotid intima-media thickness (IMT), and brainstem auditory evoked potentials (BAEP). We carried out multiple regression and structural equation model (SEM) analyses to determine the confounder-adjusted effect of mercury exposure. Taking into account correlations among related measures, we categorized exposure and outcomes in groups to derive latent exposure and response variables in SEMs. We used multiple regression analysis to compare the predictive validity of individual exposure biomarkers and the latent exposure variable on individual and latent outcomes. The toenail mercury concentrations varied widely and had a geometric mean of 2.0 μg/g; hair concentrations averaged about 3-fold higher. Mercury exposure was significantly associated with increased BP and IMT. This effect was reflected by SEMs, but mercury in toenails tended to be the best effect predictor. The results support the notion that increased MeHg exposure promotes the development of cardiovascular disease.
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影响因子：
10.4
作者：
Dalgard C;Grandjean P;Jorgensen PJ;Weihe P
通讯作者：
Weihe P
影响因子：
15.8
作者：
Heilmann C;Grandjean P;Weihe P;Nielsen F;Budtz-Jørgensen E
通讯作者：
Budtz-Jørgensen E
影响因子：
4.5
作者：
Chuu, JJ;Hsu, CJ;Lin-Shiau, SY
通讯作者：
Lin-Shiau, SY
影响因子：
2
作者：
Budtz-Jorgensen, E;Keiding, N;White, RF
通讯作者：
White, RF
DOI：
10.1007/s00420-002-0391-8
发表时间：
2003-03-01
影响因子：
3
作者：
Jhun, HJ;Yim, SH;Paek, D
通讯作者：
Paek, D