Antifouling Photograftable Zwitterionic Coatings on PDMS Substrates.
Antifouling Photograftable Zwitterionic Coatings on PDMS Substrates.
复制标题
DOI：
10.1021/acs.langmuir.8b00838
复制
发表时间：
2019-02-05
期刊：
影响因子：
--
通讯作者：
Guymon CA
中科院分区：
文献类型：
--
作者：
Leigh BL;Cheng E;Xu L;Derk A;Hansen MR;Guymon CA
对植入材料的异物反应（FBR）会对医疗器械（如人工耳蜗植入体）的性能产生负面影响。抵抗FBR的工程表面可能导致增强的功能，包括通过减少纤维化潜在地改善耳蜗植入物接受者的结果。在这项工作中，我们用两种两性离子聚合物，聚（磺基甜菜碱甲基丙烯酸酯）（pSBMA）和聚（羧基甜菜碱甲基丙烯酸酯）（pCBMA）涂覆聚（二甲基硅氧烷）（PDMS）表面，使用同时的光接枝/光交联过程，产生一个强大的接枝两性离子水凝胶。减少非特异性蛋白质吸附，是FBR的第一步。涂覆过程使用二苯甲酮、光接枝剂和II型光引发剂，以将交联的两性离子薄膜共价连接到PDMS表面。随着二苯甲酮在表面上的浓度增加，两性离子薄膜对PDMS表面的粘合强度增加，如通过剪切粘合测定的。此外，随着吸附的二苯甲酮浓度的增加，系统的失效从粘合剂分层变为水凝胶内的内聚失效，表明持久的粘合剂结合由光接枝过程形成。有趣的是，与未涂覆的对照相比，两性离子聚合物的防污性能在两性离子水凝胶涂覆的样品上保持显著较低水平的非特异性蛋白质吸附。成纤维细胞粘附在涂覆的基底上也显著降低。这些结果表明，交联的pSBMA和pCBMA水凝胶可以容易地光接枝到PDMS基底上，并且在潜在地改变对植入的生物材料的纤维化反应方面显示出希望。
The foreign body response (FBR) to implantable materials can negatively impact performance of medical devices such as the cochlear implant. Engineering surfaces that resist the FBR could lead to enhanced functionality including potentially improving outcomes for cochlear implant recipients through reduction in fibrosis. In this work, we coat poly(dimethyl siloxane) (PDMS) surfaceswith two zwitterionic polymers, poly(sulfobetaine methacrylate) (pSBMA) and poly(carboxybetaine methacrylate) (pCBMA), using a simultaneous photografting/photocross-linking process to produce a robust grafted zwitterionic hydrogel. reduce nonspecific protein adsorption, the first step of the FBR. The coating process uses benzophenone, a photografting agent and type II photoinitiator, to covalently link the crosslinked zwitterionic thin film to the PDMS surface. As the concentration of benzophenone on the surface increases, the adhesive strength of the zwitterionic thin films to PDMS surfaces increases as determined by shear adhesion. Additionally, with increased concentration of the adsorbed benzophenone, failure of the system changes from adhesive delamination to cohesive failure within the hydrogel, demonstrating that durable adhesive bonds are formed from the photografting process. Interestingly, anti-fouling properties of the zwitterionic polymers are preserved with significantly lower levels of nonspecific protein adsorption on zwitterion hydrogel-coated samples compared to uncoated controls. Fibroblast adhesion is also dramatically reduced on coated substrates. These results show that crosslinked pSBMA and pCBMA hydrogels can be readily photografted to PDMS substrates and show promise in potentially changing the fibrotic response to implanted biomaterials.
登录
查看更多内容
DOI：
10.1097/mao.0000000000000540
发表时间：
2014-10
期刊：
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
影响因子：
--
作者：
Seyyedi M;Nadol JB Jr
通讯作者：
Nadol JB Jr
DOI：
10.1097/mao.0000000000001199
发表时间：
2016-12
期刊：
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
影响因子：
--
作者：
Ishiyama A;Doherty J;Ishiyama G;Quesnel AM;Lopez I;Linthicum FH
通讯作者：
Linthicum FH
DOI：
10.1016/s0143-7496(98)00066-9
发表时间：
1999-10-01
影响因子：
3.4
作者：
Rånby, B
通讯作者：
Rånby, B
影响因子：
5.8
作者：
Goda, Tatsuro;Matsuno, Ryosuke;Ishihara, Kazuhiko
通讯作者：
Ishihara, Kazuhiko
影响因子：
14
作者：
Carr, Louisa R.;Xue, Hong;Jiang, Shaoyi
通讯作者：
Jiang, Shaoyi