Association between the Estimated Glomerular Filtration Rate and Brain Atrophy in Older Adults.
Association between the Estimated Glomerular Filtration Rate and Brain Atrophy in Older Adults.
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DOI：
10.1159/000521892
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发表时间：
2022
影响因子：
4.2
通讯作者：
中科院分区：
文献类型：
--
作者：
终末期肾病与认知障碍和脑萎缩有关。目前尚不清楚轻度至中度肾功能不全是否与脑萎缩有关，尤其是在老年人中。我们使用来自阿尔茨海默病神经影像学倡议（ADNI）的横断面数据，这是一项由NIH资助的多中心纵向队列研究，旨在更好地了解估计肾小球滤过率（eGFR）与脑体积之间的关系。我们纳入了所有ADNI参与者的基线血清肌酐值和MRI脑容量评估。我们使用多元线性回归模型来寻找慢性肾脏病流行病学协作组eGFR与全脑灰质、海马、内嗅、梭状和中颞叶脑体积之间的横断面相关性。参与者（n=1596）年龄为74±7岁，平均eGFR为69.4±14.8 ml/min/1.73 m2; 53%有轻度认知障碍，19%有痴呆。未经调整的分析显示，较低的eGFR和较小的脑体积之间存在关联。校正年龄、性别和教育后，eGFR与脑容量无关（所有p>0.05）。按年龄分层和基线认知状态进行亚组分析后，这些结果保持一致。年龄是eGFR和脑容量之间未校正相关性的混杂变量。因此，轻度至中度eGFR降低与ADNI参与者的脑萎缩无关。
End Stage Kidney disease is associated with cognitive impairment and brain atrophy. It remains unclear if mild to moderate kidney dysfunction is associated with brain atrophy especially in older adults. We used cross sectional data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI), an NIH funded multicenter longitudinal cohort study to better understand the association between estimated glomerular filtration rate (eGFR) and brain volumes. We included all ADNI participants with both baseline serum creatinine values and MRI brain volume assessments. We used multiple linear regression modeling to look for cross-sectional associations between Chronic Kidney Disease Epidemiological Collaboration eGFR and whole brain gray matter, hippocampus, entorhinal, fusiform, and middle temporal brain volumes. Participants (n=1596) were 74±7 years old with mean eGFR of 69.4±14.8 ml/min/1.73 m2; 53% had mild cognitive impairment, and 19% had dementia. Unadjusted analysis showed an association between lower eGFR and smaller brain volumes. After adjusting for age, sex, and education, eGFR was not associated with brain volumes (p>0.05 for all). These results remained consistent after sub-group analysis by age stratification and baseline cognitive status. Age was a confounding variable in the unadjusted association between eGFR and brain volumes. Thus, mild to moderately reduced eGFR was not associated with brain atrophy in ADNI participants.
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影响因子：
5.4
作者：
Yakushiji, Yusuke;Nanri, Yusuke;Node, Koichi
通讯作者：
Node, Koichi
影响因子：
3.5
作者：
Chang, C. -Y.;Lin, C. -C.;Fuh, J. -L.
通讯作者：
Fuh, J. -L.
影响因子：
13.6
作者：
Lepping, Rebecca J.;Montgomery, Robert N.;Gupta, Aditi
通讯作者：
Gupta, Aditi
影响因子：
3.7
作者：
Tsuruya K;Yoshida H;Haruyama N;Fujisaki K;Hirakata H;Kitazono T
通讯作者：
Kitazono T
影响因子：
3.7
作者：
Gupta A;Kennedy K;Perales-Puchalt J;Drew D;Beddhu S;Sarnak M;Burns J;Alzheimer’s Disease Neuroimaging Initiative
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative