Changes in knee cartilage T2 values over 24 months in subjects with and without risk factors for knee osteoarthritis and their association with focal knee lesions at baseline: data from the osteoarthritis initiative.
Changes in knee cartilage T2 values over 24 months in subjects with and without risk factors for knee osteoarthritis and their association with focal knee lesions at baseline: data from the osteoarthritis initiative.
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DOI：
10.1002/jmri.22834
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发表时间：
2012-02
影响因子：
4.4
通讯作者：
Link, Thomas M.
中科院分区：
文献类型：
--
作者：
Baum, Thomas;Stehling, Christoph;Joseph, Gabby B.;Carballido-Gamio, Julio;Schwaiger, Benedikt J.;Mueller-Hoecker, Christina;Nevitt, Michael C.;Lynch, John;McCulloch, Charles E.;Link, Thomas M.
研究有和无膝关节骨关节炎(OA)危险因素的受试者在24个月内膝关节软骨T2值的变化及其与基准膝关节局灶性病变的关系。41名无骨关节炎危险因素的受试者和101名有骨性关节炎危险因素(如膝关节损伤或手术史)的受试者来自骨关节炎倡议数据库(年龄：45-55岁，右膝无放射性骨性关节炎)。对右膝关节的基线MR图像进行评估，以了解膝关节局灶性病变的患病率和分级。在基线和24个月的随访期测量右膝关节软骨T2，测量5个隔室(膝盖骨、股骨内侧/外侧/胫骨)。与无骨性关节炎危险因素的受试者相比，有骨性骨性关节炎危险因素的受试者在膝关节局灶性病变的基线患病率和分级方面没有显著差异(p>；0.05)，但在两个时间点的股骨内侧间隙的T2值显著升高(p<；0.05)。两组所有五个间隔的T2值在24个月内显著增加，但两组间T2增加的差异并不显著。在两个时间点上，有软骨损伤的受试者的T2值显著高于无软骨损伤的受试者，但在24个月内T2没有加速增加(p>；0.05)。在有和没有骨性关节炎危险因素的受试者中，软骨T2值在24个月内显著增加，但无论是存在骨性关节炎危险因素还是基线时软骨损伤的存在都与这些T2增加无关。
To examine the changes in knee cartilage T2 values over 24 months in subjects with and without risk factors for knee osteoarthritis (OA) and their association with focal knee lesions at baseline. Forty-one subjects without, and 101 subjects with OA risk factors (such as history of knee injury or surgery) were selected from the Osteoarthritis Initiative database (age: 45-55 years, no radiographic OA in the right knee). Baseline MR images of the right knee were assessed for prevalence and grade of focal knee lesions. Right knee cartilage T2 measurements were performed in five compartments (patella, medial/lateral femur/tibia) at baseline and 24 month follow-up. Compared to subjects without OA risk factors, those with OA risk factors showed no significant differences in baseline prevalence and grade of focal knee lesions (p>0.05), but had significantly higher T2 values in the medial femur compartment at both time points (p<0.05). T2 values averaged over all five compartments increased significantly over 24 months in both groups, but differences in T2 increase between the groups were not significant. Subjects with cartilage lesions showed significantly higher T2 values compared to subjects without cartilage lesions at both time points, but no accelerated T2 increase over 24 months (p>0.05). Cartilage T2 values significantly increased over 24 months in subjects with and without OA risk factors, but neither the presence of OA risk factors nor the presence of cartilage lesions at baseline were associated with these T2 increases.
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DOI：
10.2214/ajr.08.2256
发表时间：
2009-11
期刊：
AJR. American journal of roentgenology
影响因子：
--
作者：
Friedrich KM;Shepard T;de Oliveira VS;Wang L;Babb JS;Schweitzer M;Regatte R
通讯作者：
Regatte R
影响因子：
--
作者：
Lawrence, Reva C.;Felson, David T.;Wolfe, Frederick
通讯作者：
Wolfe, Frederick
影响因子：
19.7
作者：
Mosher, TJ;Dardzinski, BJ;Smith, MB
通讯作者：
Smith, MB
影响因子：
--
作者：
Mosher, TJ;Liu, Y;Smith, MB
通讯作者：
Smith, MB
影响因子：
7
作者：
Peterfy CG;Schneider E;Nevitt M
通讯作者：
Nevitt M