A novel paperfluidic closed bipolar electrode-electrochemiluminescence sensing platform: Potential for multiplex detection at crossing-channel closed bipolar electrodes
A novel paperfluidic closed bipolar electrode-electrochemiluminescence sensing platform: Potential for multiplex detection at crossing-channel closed bipolar electrodes
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一种新型纸流体闭合双极电极-电化学发光传感平台：跨通道闭合双极电极多重检测的潜力
DOI：
10.1016/j.snb.2018.04.180
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发表时间：
2018-10
期刊：
影响因子：
--
通讯作者：
Zhang Chunsun
中科院分区：
文献类型：
--
作者：
Liu Cuiling;Wang Dan;Zhang Chunsun
在这项工作中，我们首次报道了一种基于纸张流体跨通道闭合BPE的电化学发光(P-3C-BPE-ECL)平台，该平台垂直于两个平行的通道放置多个“带”形的C-BPE，并且可以在报告通道中实现多路检测。基于蜡墨和碳墨的丝网印刷工艺可以很容易地制造出纸流控装置。在优化的条件下，P-3C-BPE-ECL用于过氧化氢和葡萄糖的定量分析，线性范围分别为0.075-10 mm和0.08-5 mm，检出限分别为0.041 mm和0.03 mm。据我们所知，这是纸流控C-BPE-ECL法测定葡萄糖的首次演示。基于其良好的选择性，将P-3C-BPE-ECL法用于四种复杂样品(人血清和尿液、葡萄酒和葡萄糖注射液)中葡萄糖的测定，并与传统方法进行了比较。结果表明，该平台具有较好的一致性，证明了该平台的可靠性和准确性。重要的是，所提出的方法被证明具有双重检测葡萄糖和尿酸的潜力，这非常符合那些同时患有糖尿病和痛风的患者的要求。因此，我们相信P-3C-BPE-ECL可以为广泛的生化应用提供一个新的平台。
In this work, we for the first time reported a paperfluidic crossing-channel closed-BPE based electrochemiluminescence (P-3C-BPE-ECL) platform where multiple “band”-shaped C-BPEs are situated perpendicular to two parallel channels, and multiplex detection can be achieved in the reporting channel. The paperfluidic devices are easily fabricated by wax and carbon ink-based screen-printing processes. Under optimized conditions, the P-3C-BPE-ECL is applied to the quantitative analysis of hydrogen peroxide (H2O2) and glucose, with corresponding linear ranges of 0.075–10 mM and 0.08–5 mM, and corresponding detection limits of 0.041 mM and 0.03 mM. To our knowledge, this is the first demonstration of paperfluidic C-BPE-ECL method for glucose determination. Based on its acceptable selectivity, the P-3C-BPE-ECL method is used for measurements of glucose in four complex samples (human serum and urine, wine, and glucose injection) and is compared with the traditional methods. The results indicate a good agreement and prove the reliability and accuracy of the proposed platform. Importantly, the proposed method is demonstrated to have the potential for duplex detection of glucose and uric acid, which intensively matches the requirement of those patients simultaneously suffering from diabetes and gout. Therefore, we believe that the P-3C-BPE-ECL could provide a new platform for wide biochemical applications.
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