Co-transcriptional regulation of alternative pre-mRNA splicing.
Co-transcriptional regulation of alternative pre-mRNA splicing.
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DOI：
10.1016/j.bbagrm.2012.01.014
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发表时间：
2012-07
影响因子：
4.7
通讯作者：
Oberdoerffer, Shalini
中科院分区：
文献类型：
--
作者：
Shukla, Sanjeev;Oberdoerffer, Shalini
虽然对替代的前mRNA剪接调控的研究通常集中在新生信息中的RNA结合蛋白及其靶序列，但越来越明显的是，mRNA剪接、RNA聚合酶II(PolII)的延长和染色质结构错综复杂地交织在一起。高等真核生物中的大多数内含子在转录释放之前被切除，这种方式依赖于PolII的转录。作为共转录剪接的结果，PolII伸长的变化影响了选择性剪接模式，其中较慢的伸长率与成熟mRNA中选择性外显子的增加有关。PolII伸长的生理障碍，如抑制性染色质结构，可以类似地影响剪接决定。令人惊讶的是，前mRNA剪接可以相互影响PolII的伸长和染色质结构。在这里，我们重点介绍了共转录剪接的最新进展，揭示了剪接、转录和染色质重塑复合体之间的广泛网络耦合。
While studies of alternative pre-mRNA splicing regulation have typically focused on RNA-binding proteins and their target sequences within nascent message, it is becoming increasingly evident that mRNA splicing, RNA polymerase II (pol II) elongation and chromatin structure are intricately intertwined. The majority of introns in higher eukaryotes are excised prior to transcript release in a manner that is dependent on transcription through pol II. As a result of co-transcriptional splicing, variations in pol II elongation influence alternative splicing patterns, wherein a slower elongation rate is associated with increased inclusion of alternative exons within mature mRNA. Physiological barriers to pol II elongation, such as repressive chromatin structure, can thereby similarly impact splicing decisions. Surprisingly, pre-mRNA splicing can reciprocally influence pol II elongation and chromatin structure. Here, we highlight recent advances in co-transcriptional splicing that reveal an extensive network of coupling between splicing, transcription and chromatin remodeling complexes.
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影响因子：
64.5
作者：
CHOW, LT;GELINAS, RE;ROBERTS, RJ
通讯作者：
ROBERTS, RJ
影响因子：
16
作者：
Ahn, SH;Kim, M;Buratowski, S
通讯作者：
Buratowski, S
影响因子：
9.8
作者：
Brody Y;Neufeld N;Bieberstein N;Causse SZ;Böhnlein EM;Neugebauer KM;Darzacq X;Shav-Tal Y
通讯作者：
Shav-Tal Y
影响因子：
16.8
作者：
通讯作者：
--
影响因子：
16
作者：
Buratowski S
通讯作者：
Buratowski S