Microstructural grey matter parcellation and its relevance for connectome analyses.

Microstructural grey matter parcellation and its relevance for connectome analyses.
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DOI:
10.1016/j.neuroimage.2013.04.003
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发表时间:
2013-10-15
期刊:
影响因子:
5.7
通讯作者:
Amunts K
Amunts K
中科院分区:
医学1区
文献类型:
--
作者:
Caspers S;Eickhoff SB;Zilles K;Amunts K

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人脑连接体与由皮层结构分离成不同的皮层区域所提供的解剖框架密切相关。因此,为分析和解释连接体数据提供全面的解剖学参考对于理解皮层不同区域的结构和功能、连接它们的白色物质纤维结构以及这些不同实体之间的相互作用是必不可少的。这篇文章的重点是大脑灰质的包裹计划和它们的相关性连接体分析。特别是,使用不同的可用地图集和包裹方案的好处和局限性进行审查。此外,还讨论了目前如何将图谱信息用于连通性分析,主要关注基于种子和种子目标的分析,基于连通性的分割结果,以及连通性数据的强大解剖解释。特别是这最后一个方面打开了将连接信息集成到给定的解剖框架中的可能性,为深入理解结构-功能关系的人脑多模态图谱铺平了道路。
The human brain connectome is closely linked to the anatomical framework provided by the structural segregation of the cortex into distinct cortical areas. Therefore, a thorough anatomical reference for the analysis and interpretation of connectome data is indispensable to understand the structure and function of different regions of the cortex, the white matter fibre architecture connecting them, and the interplay between these different entities. This article focuses on parcellation schemes of the cerebral grey matter and their relevance for connectome analyses. In particular, benefits and limitations of using different available atlases and parcellation schemes are reviewed. It is furthermore discussed how atlas information is currently used in connectivity analyses with major focus on seed-based and seed-target analyses, connectivity-based parcellation results, and the robust anatomical interpretation of connectivity data. Particularly this last aspect opens the possibility of integrating connectivity information into given anatomical frameworks, paving the way to multi-modal atlases of the human brain for a thorough understanding of structure-function relationships.
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