Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome.
Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome.
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DOI：
10.1016/j.envpol.2018.04.130
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Mutlu GM
中科院分区：
文献类型：
--
作者：
Mutlu EA;Comba IY;Cho T;Engen PA;Yazıcı C;Soberanes S;Hamanaka RB;Niğdelioğlu R;Meliton AY;Ghio AJ;Budinger GRS;Mutlu GM
最近的研究表明，颗粒物（PM）空气污染与胃肠道（GI）疾病之间存在关联。除直接沉积外，PM还可通过粘膜纤毛清除和吞咽唾液和粘液间接沉积在口咽。在胃肠道内，PM可能改变胃肠道上皮和肠道微生物群。我们的目标是在吸入PM暴露的小鼠模型中确定PM对肠道微生物群的影响。C57BL/6小鼠通过吸入高浓度环境颗粒或过滤空气暴露，每天8小时，每周5天，共3周。暴露结束时，收集胃肠道组织和粪便，并分析肠道微生物群。与暴露于空气中的小鼠相比，暴露于pm的小鼠胃肠道中α -多样性随着丰富度多样性的增加而改变。最重要的是，在整个胃肠道的β -多样性比较中，pm诱导的微生物群变化非常明显，并且从近端到远端逐渐增加。观察到属的变化，并表明不同的细菌可能具有暴露于PM时开花的能力。暴露于PM会改变整个胃肠道的微生物群，这可能是PM引起胃肠道炎症的潜在机制。
Recent studies suggest an association between particulate matter (PM) air pollution and gastrointestinal (GI) disease. In addition to direct deposition, PM can be indirectly deposited in oropharynx via mucociliary clearance and upon swallowing of saliva and mucus. Within the GI tract, PM may alter the GI epithelium and gut microbiome. Our goal was to determine the effect of PM on gut microbiota in a murine model of PM exposure via inhalation. C57BL/6 mice were exposed via inhalation to either concentrated ambient particles or filtered air for 8-hours per day, 5-days a week, for a total of 3-weeks. At exposure’s end, GI tract tissues and feces were harvested, and gut microbiota was analyzed. Alpha-diversity was altered with increased richness diversity in PM-exposed mice compared to air-exposed mice in the GI tract. Most importantly, PM-induced alterations in the microbiota were very apparent in beta-diversity comparisons throughout the GI tract and appeared to increase from the proximal to distal parts. Changes in genera were seen and suggest that distinct bacteria may have the capacity to bloom with PM exposure. Exposure to PM alters the microbiota throughout the GI tract which maybe a potential mechanism that explains PM induced inflammation in the GI tract.
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影响因子：
3
作者：
Binaku, Katrina;O'Brien, Timothy;Fosco, Tinamarie
通讯作者：
Fosco, Tinamarie
影响因子：
10.4
作者：
Dai L;Zanobetti A;Koutrakis P;Schwartz JD
通讯作者：
Schwartz JD
影响因子：
4.9
作者：
Ananthakrishnan, Ashwin N.;McGinley, Emily L.;Saeian, Kia
通讯作者：
Saeian, Kia
影响因子：
0.5
作者：
Agarwal, Neil K.;Sharma, Prerna;Agarwal, Shashi K.
通讯作者：
Agarwal, Shashi K.
DOI：
10.1016/0034-5687(85)90041-6
发表时间：
1985-01-01
期刊：
RESPIRATION PHYSIOLOGY
影响因子：
--
作者：
DEPLEDGE, MH
通讯作者：
DEPLEDGE, MH