Exploring the evidence for epigenetic regulation of environmental influences on child health across generations.
Exploring the evidence for epigenetic regulation of environmental influences on child health across generations.
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探索跨代环境对儿童健康影响的表观遗传调控证据。
DOI：
10.1038/s42003-021-02316-6
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发表时间：
2021-06-22
影响因子：
5.9
通讯作者：
Fry R
中科院分区：
文献类型：
--
作者：
Breton CV;Landon R;Kahn LG;Enlow MB;Peterson AK;Bastain T;Braun J;Comstock SS;Duarte CS;Hipwell A;Ji H;LaSalle JM;Miller RL;Musci R;Posner J;Schmidt R;Suglia SF;Tung I;Weisenberger D;Zhu Y;Fry R
环境暴露、社会心理压力源和营养都是潜在的重要影响因素，可能直接或通过与基因组或表观基因组的相互作用影响几代人的健康结果。虽然近几十年来在大规模的人类遗传研究中取得了明显的成功，但仍有大量缺失的遗传性需要阐明复杂的儿童疾病。越来越多的证据（主要是在动物身上）表明，环境暴露可能在一代或几代人中产生或延续改变的健康结果。这些环境健康影响的一个假定机制是通过改变的表观遗传调控。本综述重点介绍了当前的流行病学文献和描述环境暴露对代际和跨代健康影响的支持性动物研究。考虑到母亲和父亲的接触和传播模式，并注意随之而来的伦理、法律和社会影响。Carrie Breton及其同事回顾了通过表观遗传机制支持环境暴露对跨代健康影响的文献。这篇综述总结了目前基于动物和人类队列研究的知识，并讨论了人类表观遗传研究的伦理、法律和社会意义
Environmental exposures, psychosocial stressors and nutrition are all potentially important influences that may impact health outcomes directly or via interactions with the genome or epigenome over generations. While there have been clear successes in large-scale human genetic studies in recent decades, there is still a substantial amount of missing heritability to be elucidated for complex childhood disorders. Mounting evidence, primarily in animals, suggests environmental exposures may generate or perpetuate altered health outcomes across one or more generations. One putative mechanism for these environmental health effects is via altered epigenetic regulation. This review highlights the current epidemiologic literature and supporting animal studies that describe intergenerational and transgenerational health effects of environmental exposures. Both maternal and paternal exposures and transmission patterns are considered, with attention paid to the attendant ethical, legal and social implications. Carrie Breton and colleagues review the literature supporting evidence for transgenerational health effects of environmental exposures by epigenetic mechanisms. This Review summarizes current knowledge based on animal and human cohort studies, and discusses the ethical, legal, and social implications of epigenetic research in humans
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影响因子：
1.8
作者：
Agius, R.;Savona-Ventura, C.;Vassallo, J.
通讯作者：
Vassallo, J.
DOI：
10.1016/j.jaci.2016.12.002
发表时间：
2017-02
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Arshad SH;Karmaus W;Zhang H;Holloway JW
通讯作者：
Holloway JW
影响因子：
3.5
作者：
Banik A;Kandilya D;Ramya S;Stünkel W;Chong YS;Dheen ST
通讯作者：
Dheen ST
影响因子：
24.3
作者：
Blacquiere, M. J.;Timens, W.;Hylkema, M. N.
通讯作者：
Hylkema, M. N.
影响因子：
3.5
作者：
Bellinger DC
通讯作者：
Bellinger DC