Tumor- and Osteoblast-Derived Periostin in Prostate Cancer bone Metastases.
Tumor- and Osteoblast-Derived Periostin in Prostate Cancer bone Metastases.
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前列腺癌骨转移中肿瘤和成骨细胞衍生的骨膜素
DOI：
10.3389/fonc.2021.795712
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发表时间：
2021
影响因子：
4.7
通讯作者：
Xia GW
中科院分区：
文献类型：
--
作者：
Sun CY;Mi YY;Ge SY;Hu QF;Xu K;Guo YJ;Tan YF;Zhang Y;Zhong F;Xia GW
Exploring the biological function of periostin (POSTN) in prostate cancer (PCa) bone metastasis is of importance. It was observed that the expression of POSTN was high in PCa, especially highest in PCa metastasized to bone. In this study, we found that inhibiting POSTN in PCa cells could significantly alleviate PCa bone metastasis in vivo, suggesting POSTN is a promising therapeutic target. Since, due to the secreted expression of POSTN in osteoblasts and PCa, we hypothesized the positive feedback loop between osteoblasts and PCa mediated by POSTN in PCa bone metastasis. The in vitro experiments demonstrated that osteoblast-derived POSTN promoted PCa cell proliferation and invasion and PCa cell-derived POSTN promotes proliferation of osteoblasts. Furthermore, we found that POSTN regulated PCa and osteoblast function through integrin receptors. Finally, 18F-Alfatide II was used as the molecule probe of integrin αvβ3 in PET-CT, revealing high intake in metastatic lesions. Our findings together indicate that targeting POSTN in PCa cells as well as in the osteoblastic may be an effective treatment for PCa bone metastasis.
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影响因子：
5.6
作者：
Lin TH;Tan TW;Tsai TH;Chen CC;Hsieh TF;Lee SS;Liu HH;Chen WC;Tang CH
通讯作者：
Tang CH
影响因子：
4.7
作者：
Ganguly SS;Li X;Miranti CK
通讯作者：
Miranti CK
c-Src 通过激活 PFKFB3 促进肿瘤发生和肿瘤进展
影响因子：
8.8
作者：
Ma, Huanhuan;Zhang, Jia;Li, Qinxi
通讯作者：
Li, Qinxi
影响因子：
11.2
作者：
San Martin R;Pathak R;Jain A;Jung SY;Hilsenbeck SG;Piña-Barba MC;Sikora AG;Pienta KJ;Rowley DR
通讯作者：
Rowley DR
影响因子：
50.3
作者：
Bao, SD;Ouyang, G;Wang, XF
通讯作者：
Wang, XF