Can permeability measurements add to blood volume measurements in differentiating tumefactive demyelinating lesions from high grade gliomas using perfusion CT?
Can permeability measurements add to blood volume measurements in differentiating tumefactive demyelinating lesions from high grade gliomas using perfusion CT?
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DOI：
10.1007/s11060-009-0030-2
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发表时间：
2010-05
影响因子：
3.9
通讯作者：
Mikkelsen T
中科院分区：
文献类型：
--
作者：
Jain R;Ellika S;Lehman NL;Scarpace L;Schultz LR;Rock JP;Rosenblum M;Mikkelsen T
肿瘤脱髓鞘病变（TDLs）可以模仿肿瘤的常规影像，可能需要活检诊断。本研究的目的是基于灌注CT的生理（通透性）和血流动力学（血容量）参数来区分tdl和高级别胶质瘤。5例患者在最初的MRI上表现为肿瘤增强病变，并进行了灌注CT检查。我们将这些患者的灌注CT参数与24例高级别胶质瘤患者的灌注CT参数进行比较。与高级别胶质瘤相比，tdl的通透性表面积积（PS）（0.8±0.2 vs 2.4±1.4 ml/100 g/min， p值0.014）和脑血容量（CBV）（1.0±0.2 vs 2.8±1.2 ml/100 g， p值0.006）较低。与高级别胶质瘤相比，tdl表现出较低的PS和CBV，在常规MR成像上可以模仿高级别胶质瘤，因为缺乏新生血管生成和血管内皮细胞增殖，因此灌注CT可以用于区分这两种实体。
Tumefactive demyelinating lesions (TDLs) can mimic a neoplasm on conventional imaging and may necessitate biopsy for diagnosis. The purpose of this study was to differentiate TDLs from high grade gliomas based on physiologic (permeability) and hemodynamic (blood volume) parameters using perfusion CT. Five patients who presented with tumefactive enhancing lesions on initial MRI that mimicked a neoplasm underwent perfusion CT. We compared the perfusion CT parameters of these patients with those of 24 patients with high grade gliomas. TDLs showed lower permeability surface area product (PS) (0.8 ± 0.2 vs 2.4 ± 1.4 ml/100 g/min, P-value 0.014) and lower cerebral blood volume (CBV) (1.0 ± 0.2 vs 2.8 ± 1.2 ml/100 g, P-value 0.006) as compared to high grade gliomas. TDLs show lower PS and CBV as compared to high grade gliomas, to which they can mimic on conventional MR imaging, due to lack of neoangiogenesis and vascular endothelial proliferation and hence perfusion CT can be used to differentiate the two entities.
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影响因子：
4.8
作者：
Roberts, HC;Roberts, TPL;Dillon, WP
通讯作者：
Dillon, WP
影响因子：
5.6
作者：
ZAGZAG, D;MILLER, DC;BUDZILOVICH, GN
通讯作者：
BUDZILOVICH, GN
影响因子：
3.5
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Horska, A.
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作者：
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通讯作者：
RODRIGUEZ, M
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作者：
Provenzale, JM;Wang, GR;Sorensen, AG
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Sorensen, AG