Sensory and descending motor circuitry during development and injury.

Sensory and descending motor circuitry during development and injury.
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DOI:
10.1016/j.conb.2018.08.008
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发表时间:
2018-12
影响因子:
5.7
通讯作者:
Kaltschmidt JA
Kaltschmidt JA
中科院分区:
医学2区
文献类型:
--
作者:
Plant GW;Weinrich JA;Kaltschmidt JA

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本体感觉输入和下行脊髓上投射是馈入并影响脊髓回路和运动行为的两个主要输入。在这里,我们回顾了它们在发育过程中和脊髓损伤后对彼此的影响。我们强调回路形成的发育机制,因为它们与感觉运动回路及其与局部脊髓中间神经元的相互相互作用有关,以及在脊髓损伤的情况下本体感觉和下行脊髓上输入之间的竞争性相互作用。
Proprioceptive sensory input and descending supraspinal projections are two major inputs that feed into and influence spinal circuitry and locomotor behaviors. Here we review their influence on each other during development and after spinal cord injury. We highlight developmental mechanisms of circuit formation as they relate to the sensory-motor circuit and its reciprocal interactions with local spinal interneurons, as well as competitive interactions between proprioceptive and descending supraspinal inputs in the setting of spinal cord injury.
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