Cerebral Hemodynamics in Speech-Related Cortical Areas: Articulation Learning Involves the Inferior Frontal Gyrus, Ventral Sensory-Motor Cortex, and Parietal-Temporal Sylvian Area.
Cerebral Hemodynamics in Speech-Related Cortical Areas: Articulation Learning Involves the Inferior Frontal Gyrus, Ventral Sensory-Motor Cortex, and Parietal-Temporal Sylvian Area.
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言语相关皮质区域中的脑血液动力学：关节学习涉及下额回，腹侧感觉运动皮层和狭窄的西尔维亚阶前。
DOI：
10.3389/fneur.2018.00939
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发表时间：
2018
影响因子：
3.4
通讯作者：
Nishijo H
中科院分区：
文献类型：
--
作者：
Nakamichi N;Takamoto K;Nishimaru H;Fujiwara K;Takamura Y;Matsumoto J;Noguchi M;Nishijo H
虽然运动训练计划已被应用于儿童言语失用症（AOS），但发音学习的神经机制尚不清楚。为此，我们记录了健康受试者（n = 15）在发音学习过程中左半球的脑血流动力学活动。我们使用近红外光谱（NIRS），同时使用频谱图记录和分析铰接的声音。该研究包括两个实验阶段（修改阶段和控制阶段），参与者被要求在有和没有咬合夹板的情况下重复音节“i-chi-ni”的发音。这种夹板用于增加咬合的垂直尺寸，以模拟关节障碍的情况。发音错误在修改阶段出现较多，但在修改阶段后半段出现的发音错误有所减少；这表明发生了发音学习。血流动力学近红外光谱数据显示，在关节过程中，额叶、顶叶和颞叶皮层明显激活。这些区域涉及语音处理和发音计划和执行，包括以下区域：(i)腹侧感觉运动皮层（vSMC），包括罗兰底盖、中央前回和中央后回；（ii）背侧感觉运动皮层，包括中央前回和中央后回；（iii）额下回的眼部（IFGoperc）； （iv）颞叶皮层，包括颞上回；(v)下顶叶（IPL），包括边缘上回和角回。在改进的会话中，选择性地激活顶叶-颞叶边界的后外侧裂（Spt区）。此外，IFGoperc和vSMC的血流动力学活性在改良课程的后半部分比前半部分有所增加，并且与改良课程中发音学习中的发音错误负相关。目前的研究结果表明，包括IFGoperc和vSMC在内的额叶区域在发音学习中具有重要作用，并通过Spt和IPL区域进行感觉反馈。本研究为儿童言语失用的潜在病理和治疗提供了线索。
Although motor training programs have been applied to childhood apraxia of speech (AOS), the neural mechanisms of articulation learning are not well understood. To this aim, we recorded cerebral hemodynamic activity in the left hemisphere of healthy subjects (n = 15) during articulation learning. We used near-infrared spectroscopy (NIRS) while articulated voices were recorded and analyzed using spectrograms. The study consisted of two experimental sessions (modified and control sessions) in which participants were asked to repeat the articulation of the syllables “i-chi-ni” with and without an occlusal splint. This splint was used to increase the vertical dimension of occlusion to mimic conditions of articulation disorder. There were more articulation errors in the modified session, but number of errors were decreased in the final half of the modified session; this suggests that articulation learning took place. The hemodynamic NIRS data revealed significant activation during articulation in the frontal, parietal, and temporal cortices. These areas are involved in phonological processing and articulation planning and execution, and included the following areas: (i) the ventral sensory-motor cortex (vSMC), including the Rolandic operculum, precentral gyrus, and postcentral gyrus, (ii) the dorsal sensory-motor cortex, including the precentral and postcentral gyri, (iii) the opercular part of the inferior frontal gyrus (IFGoperc), (iv) the temporal cortex, including the superior temporal gyrus, and (v) the inferior parietal lobe (IPL), including the supramarginal and angular gyri. The posterior Sylvian fissure at the parietal–temporal boundary (area Spt) was selectively activated in the modified session. Furthermore, hemodynamic activity in the IFGoperc and vSMC was increased in the final half of the modified session compared with its initial half, and negatively correlated with articulation errors during articulation learning in the modified session. The present results suggest an essential role of the frontal regions, including the IFGoperc and vSMC, in articulation learning, with sensory feedback through area Spt and the IPL. The present study provides clues to the underlying pathology and treatment of childhood apraxia of speech.
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影响因子：
2.9
作者：
Ishikuro K;Urakawa S;Takamoto K;Ishikawa A;Ono T;Nishijo H
通讯作者：
Nishijo H
影响因子：
5.3
作者：
Conant, David F.;Bouchard, Kristofer E.;Chang, Edward F.
通讯作者：
Chang, Edward F.
影响因子：
4.8
作者：
Goble, Daniel J.;Coxon, James P.;Swinnen, Stephan P.
通讯作者：
Swinnen, Stephan P.
影响因子：
14.5
作者：
DAMASIO, H;DAMASIO, AR
通讯作者：
DAMASIO, AR
影响因子：
11.2
作者：
Catani, M;Jones, DK;Ffytche, DH
通讯作者：
Ffytche, DH