Comparative pathology of bacteria in the genus Providencia to a natural host, Drosophila melanogaster.
Comparative pathology of bacteria in the genus Providencia to a natural host, Drosophila melanogaster.
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DOI：
10.1016/j.micinf.2011.02.005
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发表时间：
2011-07
影响因子：
5.8
通讯作者：
Lazzaro BP
中科院分区：
文献类型：
--
作者：
Galac MR;Lazzaro BP
普罗威登斯菌属的细菌是许多生物体的病原体，包括人类和昆虫。我们和同事们已经分离出五种不同的菌株，属于四种不同的普罗维登属物种，作为在野外捕获的黑腹果蝇的自然感染。我们发现这些分离株在感染D.果蝇与黑腹果蝇不同，不同之处在于它们引起的死亡率水平、它们在宿主体内复制的能力以及引起果蝇免疫反应的水平。一种有趣的细菌是喷嚏普罗威登斯菌（Providencia sneebia），它几乎完全导致死亡，并在苍蝇中达到大量，但不会引起强烈的免疫反应。通过共感染实验，我们确定了P. sneebia避免了免疫系统的识别。我们测试了生物膜的形成和复制D。黑腹细胞作为可能的机制P. sneebia逃避宿主免疫，但没有找到证据。D. melanogaster和Providencia提供了一个强大的系统，用于研究一般的宿主-病原体相互作用，并了解如何充分研究免疫模型宿主D。黑腹菌与其天然细菌病原体相互作用。
Bacteria in the genus Providencia are pathogens of many organisms, including humans and insects. We and colleagues have isolated five different strains belonging to four distinct Providencia species as natural infections of Drosophila melanogaster captured in the wild. We found that these isolates vary considerably in pathology to infected D. melanogaster, differing in the level of mortality they cause, their ability to replicate within the host and the level that the fly’s immune response is elicited. One interesting bacterium was Providencia sneebia, which causes nearly complete mortality and reaches large numbers in the fly but does not elicit a comparably strong immune response. Through coinfection experiments, we determined that P. sneebia avoids recognition by the immune system. We tested for biofilm formation and replication within D. melanogaster cells as possible mechanisms for P. sneebia escape from host immunity, but did not find evidence for either. D. melanogaster and Providencia provide a powerful system for studying general host-pathogen interactions, and for understanding how the well-studied immune model host D. melanogaster interacts with its natural bacterial pathogens.
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影响因子：
3.4
作者：
Berkey CD;Blow N;Watnick PI
通讯作者：
Watnick PI
影响因子：
3.1
作者：
ALBERT, MJ;ALAM, K;MATHAN, MM
通讯作者：
MATHAN, MM
影响因子：
3
作者：
Interaminense, J. A.;Nascimento, D. C. O.;Lima-Filho, J. V.
通讯作者：
Lima-Filho, J. V.
DOI：
10.1073/pnas.0604865103
发表时间：
2006-10-10
影响因子：
11.1
作者：
Broderick, Nichole A.;Raffa, Kenneth F.;Handelsman, Jo
通讯作者：
Handelsman, Jo
影响因子：
4.4
作者：
Corby-Harris, Vanessa;Pontaroli, Ana Clara;Promislow, Daniel E. L.
通讯作者：
Promislow, Daniel E. L.