Genetic analysis of Drosophila melanogaster susceptibility to intestinal Vibrio cholerae infection.
Genetic analysis of Drosophila melanogaster susceptibility to intestinal Vibrio cholerae infection.
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DOI：
10.1111/j.1462-5822.2008.01267.x
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发表时间：
2009-03
影响因子：
3.4
通讯作者：
Watnick PI
中科院分区：
文献类型：
--
作者：
Berkey CD;Blow N;Watnick PI
我们之前证明霍乱弧菌能够定植于果蝇的肠道并产生致命的感染。在这里，我们展示了基因筛查的结果，该筛查旨在确定改变果蝇对肠道霍乱弧菌感染易感性的因素。在这种感染模型中，艾格峰/文根信号通路保护果蝇免受感染。此外，IMD信号通路内的突变增加了对肠道霍乱弧菌感染的抵抗力，并增加了感染期间肠上皮内的程序性细胞死亡。我们认为程序性细胞死亡可以保护肠上皮免受霍乱弧菌感染，因此果蝇可以作为一个有用的模型来研究共生和致病性肠道细菌对肠上皮细胞存活的调节以及导致肠上皮侵蚀和肠道恶性肿瘤的病理过程。
We previously demonstrated that Vibrio cholerae is able to colonize the intestine of the fly to produce a lethal infection. Here we present the results of a genetic screen undertaken to identify factors that alter susceptibility of the fly to intestinal V. cholerae infection. In this model of infection, the Eiger/Wengen signalling pathway protects the fly against infection. Furthermore, mutations within the IMD signalling pathway increase resistance to intestinal V. cholerae infection and increase programmed cell death within the intestinal epithelium during infection. We propose that programmed cell death protects the intestinal epithelium against V. cholerae infection and therefore that the fly may serve as a useful model in which to study modulation of intestinal epithelial cell survival by commensal and pathogenic intestinal bacteria as well as the pathological processes leading to erosion of the intestinal epithelium and intestinal malignancy.
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影响因子：
30.5
作者：
Kaneko, Takashi;Yano, Tamaki;Silverman, Neal
通讯作者：
Silverman, Neal
影响因子：
16
作者：
Hedengren, M;Åsling, B;Hultmark, D
通讯作者：
Hultmark, D
影响因子：
4.3
作者：
Barnich, Nicolas;Darfeuille-Michaud, Arlette
通讯作者：
Darfeuille-Michaud, Arlette
果蝇的弧菌霍拉氏菌感染模仿人类疾病霍乱。
影响因子：
6.7
作者：
Blow, Nathan S;Salomon, Robert N;Garrity, Kerry;Reveillaud, Isabelle;Kopin, Alan;Jackson, F Rob;Watnick, Paula I
通讯作者：
Watnick, Paula I
影响因子：
3.9
作者：
Aggrawal, K.;Silverman, N.
通讯作者：
Silverman, N.