Female gender is associated with long COVID syndrome: a prospective cohort study.
Female gender is associated with long COVID syndrome: a prospective cohort study.
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DOI：
10.1016/j.cmi.2021.11.002
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发表时间：
2022-04
期刊：
影响因子：
--
通讯作者：
Monforte AD
中科院分区：
文献类型：
--
作者：
Bai F;Tomasoni D;Falcinella C;Barbanotti D;Castoldi R;Mulè G;Augello M;Mondatore D;Allegrini M;Cona A;Tesoro D;Tagliaferri G;Viganò O;Suardi E;Tincati C;Beringheli T;Varisco B;Battistini CL;Piscopo K;Vegni E;Tavelli A;Terzoni S;Marchetti G;Monforte AD
我们探索了女性与慢性COVID综合征的相关性，长期COVID综合征的定义是从急性新冠肺炎病康复后持续身体和/或心理症状超过4周。第二个目的是通过多变量Logistic回归分析确定长期COVID综合征的预测因素。这是一项在意大利米兰圣保罗医院进行的单中心前瞻性队列研究。我们招募了在2020年4月15日至2020年12月15日期间在我们传染病科的COVID后门诊接受评估的成年患者。参与者是临床上从新冠肺炎康复并进行了病毒学清除的个人。以前感染过SARS-CoV-2的患者通过鼻咽拭子的逆转录聚合酶链式反应(RT-PCR)检测呈阳性，从而获得微生物学证明。所有登记的患者在随访时都进行了血液测试和全面的体检。对已缓解和持续的症状进行访谈，并要求他们填写两份问卷，以评估医院焦虑和抑郁症状(HADS)评分和事件量表修订(IES-R)评分的影响。共有377名患者参加了这项研究。从症状发作到病毒学恢复的中位时间为44(37-53)天。377例患者中260例(69%)确诊为长冠状病毒综合征。最常见的症状是乏力(149/377，39.5%)、用力呼吸困难(109/377，28.9%)、肌肉骨骼疼痛(80/377，21.2%)和“脑雾”(76/377，20.2%)。71/377人(18.8%)有焦虑症状，而40/377人(10.6%)有抑郁症状。三分之一的患者(85/275，31%)被诊断为创伤后应激障碍(由病理性IES-R评分定义)。多变量分析显示，女性与慢性冠脉综合征独立相关(AOR3.3对男性，95%可信区间1.8-6.2，P<0.0001)。高龄(10岁以上调整后(A)OR1.03，95%可信区间1.01-1.05，p0.01)和主动吸烟(既往吸烟者与活跃吸烟者的AOR0.19，95%CI0.06-0.62，p 0.002)也与长期COVID的风险增加相关，而疾病的严重程度与长期COVID无关(持续正压/无创机械通气/经口气管插管与不治疗相比，95%CI0.29-1.55，P<0.05)。P<0.85)。与罹患“慢性冠状病毒病”综合征风险较高相关的因素是女性、年龄较大和经常吸烟，但与急性疾病的严重程度无关。具有上述特征的SARS-CoV-2感染患者应及早发现，并参与后续计划。
We explored the association between female gender and long COVID syndrome, defined as persistence of physical and/or psychological symptoms for more than 4 weeks after recovery from acute COVID-19 disease. The secondary aim was to identify predictors of long COVID syndrome by multivariable logistic regression analysis. This was a single-centre prospective cohort study conducted at San Paolo Hospital in Milan, Italy. We enrolled adult patients who were evaluated at the post-COVID outpatient service of our Infectious Diseases Unit between 15 April 2020 and 15 December 2020. Participants were individuals who had clinically recovered from COVID-19 and in whom virological clearance had occurred. Previous infection by SARS-CoV-2 was microbiologically documented by positivity using a reverse-transcriptase polymerase chain reaction (RT-PCR) assay of nasopharyngeal swab. All enrolled patients underwent blood tests and a comprehensive medical examination at follow-up. Individuals were interviewed about resolved and persisting symptoms and were asked to fill in two questionnaires to allow assessment of the Hospital Anxiety and Depression symptoms (HADS) score and of the Impact of Event Scale–Revised (IES-R) score. A total of 377 patients were enrolled in the study. The median time from symtpom onset to virological clerance was 44 (37–53) days. A diagnosis of long COVID syndrome was made in 260/377 (69%) patients. The most common reported symptoms were fatigue (149/377, 39.5%), exertional dyspnoea (109/377, 28.9%), musculoskeletal pain (80/377, 21.2%) and “brain fog” (76/377, 20.2%). Anxiety symptoms were ascertained in 71/377 (18.8%) individuals, whereas 40/377 (10.6%) patients presented symptoms of depression. Post-traumatic stress disorder (defined by a pathological IES-R score) was diagnosed in one-third of patients (85/275, 31%). Female gender was independently associated with long COVID syndrome at multivariable analysis (AOR 3.3 vs. males, 95% CI 1.8–6.2, p < 0.0001). Advanced age (adjusted (A)OR 1.03 for 10 years older, 95% CI 1.01–1.05, p 0.01) and active smoking (AOR 0.19 for former smokers vs. active smokers, 95% CI 0.06–0.62, p 0.002) were also associated with a higher risk of long COVID, while no association was found between severity of disease and long COVID (AOR 0.67 for continuous positive airway pressure (CPAP)/non-invasive mechanical ventilation (NIMV)/orotracheal intubation (OTI) vs. no 02 therapy, 95% CI 0.29–1.55, p 0.85). Factors that were found to be associated with a higher risk of developing “long COVID” syndrome were female gender, older age and active smoking, but not severity of the acute disease. Individuals affected by SARS-CoV-2 infection with the aforementioned features should be early identified and involved in follow-up programmes.
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影响因子：
2.6
作者：
Moldofsky H;Patcai J
通讯作者：
Patcai J
影响因子：
29
作者：
Drucker DJ
通讯作者：
Drucker DJ
DOI：
10.1016/j.jinf.2021.01.004
发表时间：
2021-03
期刊：
The Journal of infection
影响因子：
--
作者：
Moreno-Pérez O;Merino E;Leon-Ramirez JM;Andres M;Ramos JM;Arenas-Jiménez J;Asensio S;Sanchez R;Ruiz-Torregrosa P;Galan I;Scholz A;Amo A;González-delaAleja P;Boix V;Gil J;COVID19-ALC research group
通讯作者：
COVID19-ALC research group
影响因子：
12.7
作者：
Tomasoni, Daniele;Bai, Francesca;d'Arminio Monforte, Antonella
通讯作者：
d'Arminio Monforte, Antonella
影响因子：
3.7
作者：
Townsend L;Dyer AH;Jones K;Dunne J;Mooney A;Gaffney F;O'Connor L;Leavy D;O'Brien K;Dowds J;Sugrue JA;Hopkins D;Martin-Loeches I;Ni Cheallaigh C;Nadarajan P;McLaughlin AM;Bourke NM;Bergin C;O'Farrelly C;Bannan C;Conlon N
通讯作者：
Conlon N