Impaired social contacts with familiar anesthetized conspecific in CA3-restricted brain-derived neurotrophic factor knockout mice.
Impaired social contacts with familiar anesthetized conspecific in CA3-restricted brain-derived neurotrophic factor knockout mice.
复制标题
DOI：
10.1111/gbb.12513
复制
发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Morozov A
中科院分区：
文献类型：
--
作者：
Ito W;Huang H;Brayman V;Morozov A
熟悉度是通过社会暗示传达的，并决定了对相同细节的行为。在这里，我们描述了一种新的测试小鼠社会行为的方法--与麻醉的同种动物接触--它消除了包括雄性之间的攻击在内的相互作用，并揭示了与演示者的活动无关的行为。在最初的10分钟内(第一阶段)，野生型受试者与麻醉的同种异物进行了积极的接触，无论他们是否熟悉。然而，在随后的80分钟(阶段2)中，他们更多地接触到熟悉的相似细节，而不是陌生的相似细节。然后，我们将这项测试应用于具有脑源性神经营养因子(BDNF)海马区CA3限制性敲除(KO)的高攻击性小鼠，在这种敲除中，攻击性可能掩盖其他社会行为。在第二阶段，KO小鼠表现出比野生型小鼠更少的接触熟悉的共同特异体的偏好，但在第一阶段没有差异。在非社会行为中，野生型小鼠在熟悉的环境下进食的时间也比不熟悉的同种生物少，这在基因敲除小鼠中是看不到的。此外，基因敲除小鼠的疼痛敏感度降低。综上所述，这些发现表明，CA3特异性的BDNF缺失会导致处理来自熟悉的共同特征和疼痛的社交线索的回路出现缺陷，并可能是共情类行为的基础。
Familiarity is conveyed by social cues and determines behaviors towards conspecifics. Here we characterize a novel assay for social behaviors in mice – contacts with anesthetized conspecific – which eliminates reciprocal interactions including inter-male aggression and reveals behaviors that are independent of the demonstrator’s activity. During the initial 10 minutes (phase-1), the wild-type subjects contacted the anesthetized conspecifics vigorously regardless of familiarity. During the subsequent 80 minutes (phase-2), however, they contacted more with familiar than unfamiliar conspecifics. We then applied this test to highly aggressive mice with a hippocampal CA3-restricted knockout (KO) of brain-derived neurotrophic factor (BDNF), in which aggression may mask other social behaviors. The KO mice showed less preference for contacting familiar conspecifics than did wild-type mice during phase-2 but no differences during phase-1. Among non-social behaviors, wild-type mice also spent less time eating in the presence of familiar than with unfamiliar conspecifics, which was not seen in knockout mice. Additionally, knockout mice exhibited reduced pain sensitization. Altogether, these findings suggest that CA3-specific deletion of BDNF results in deficits in circuits that process social cues from familiar conspecifics as well as pain and may underlie empathy-like behaviors.
登录
查看更多内容
影响因子：
64.5
作者：
Nakajima M;Görlich A;Heintz N
通讯作者：
Heintz N
影响因子：
2.9
作者：
MAESTRIPIERI, D;DESIMONE, R;ALLEVA, E
通讯作者：
ALLEVA, E
DOI：
10.1073/pnas.83.16.6184
发表时间：
1986-08-01
影响因子：
11.1
作者：
ALOE, L;ALLEVA, E;LEVIMONTALCINI, R
通讯作者：
LEVIMONTALCINI, R
影响因子：
11
作者：
Brumback AC;Ellwood IT;Kjaerby C;Iafrati J;Robinson S;Lee AT;Patel T;Nagaraj S;Davatolhagh F;Sohal VS
通讯作者：
Sohal VS
与疼痛中的笼友进行社交互动，通过激活大鼠内侧前额叶皮层，促进随后的脊髓伤害感受
影响因子：
7.4
作者：
Li, Zhen;Lu, Yun-Fei;Chen, Jun
通讯作者：
Chen, Jun