Oxytocin modulates female sociosexual behavior through a specific class of prefrontal cortical interneurons.
Oxytocin modulates female sociosexual behavior through a specific class of prefrontal cortical interneurons.
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DOI：
10.1016/j.cell.2014.09.020
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发表时间：
2014-10-09
期刊：
影响因子：
64.5
通讯作者：
Heintz N
中科院分区：
文献类型：
--
作者：
Nakajima M;Görlich A;Heintz N
人类成像研究表明，鼻内注射“亲社会”激素催产素（OT）会激活额叶皮层，OT的这种作用与自闭症患者大脑功能的增强有关。在这里，我们报告的生长抑素（Sst）阳性，定期尖峰interneurons表达催产素受体（OxtrINs）的人口的发现。雌性小鼠内侧前额叶皮层（mPFC）中OxtrIN的沉默导致雄性小鼠失去社会兴趣，特别是在发情周期的性接受阶段。这种社会性缺陷也存在于小鼠中的Oxtr基因有条件地删除的mPFC，并在对照组小鼠注入Oxtr拮抗剂。我们的数据表明，性别，细胞类型和状态特定的作用OT/Oxtr信号在mPFC，并确定潜在的皮质电路元件，可能会调节其他复杂的社会行为，以应对OT。
Human imaging studies have revealed that intranasal administration of the “prosocial” hormone oxytocin (OT) activates the frontal cortex, and that this action of OT correlates with enhanced brain function in autism. Here we report the discovery of a population of somatostatin (Sst) positive, regular spiking interneurons that express the oxytocin receptor (OxtrINs). Silencing of OxtrINs in the medial prefrontal cortex (mPFC) of female mice resulted in loss of social interest in male mice specifically during the sexually receptive phase of the estrous cycle. This sociosexual deficit was also present in mice in which the Oxtr gene was conditionally deleted from the mPFC, and in control mice infused with an Oxtr antagonist. Our data demonstrate a gender, cell type and state specific role for OT/Oxtr signaling in the mPFC, and identify a latent cortical circuit element that may modulate other complex social behaviors in response to OT.
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影响因子：
16.2
作者：
Insel, Thomas R.
通讯作者：
Insel, Thomas R.
影响因子：
13.9
作者：
Fishell G;Rudy B
通讯作者：
Rudy B
DOI：
10.1073/pnas.1312857110
发表时间：
2013-12-24
影响因子：
11.1
作者：
Gordon, Ilanit;Vander Wyk, Brent C.;Pelphrey, Kevin A.
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Pelphrey, Kevin A.
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作者：
CROWLEY, WR;ODONOHUE, TL;JACOBOWITZ, DM
通讯作者：
JACOBOWITZ, DM
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34.7
作者：
Ascoli, Giorgio A.;Alonso-Nanclares, Lidia;Anderson, Stewart A.;Barrionuevo, German;Benavides-Piccione, Ruth;Burkhalter, Andreas;Buzsaki, Gyoergy;Cauli, Bruno;DeFelipe, Javier;Fairen, Alfonso;Feldmeyer, Dirk;Fishell, Gord;Fregnac, Yves;Freund, Tamas F.;Gardner, Daniel;Gardner, Esther P.;Goldberg, Jesse H.;Helmstaedter, Moritz;Hestrin, Shaul;Karube, Fuyuki;Kisvarday, Zoltan F.;Lambolez, Bertrand;Lewis, David A.;Marin, Oscar;Markram, Henry;Munoz, Alberto;Packer, Adam;Petersen, Carl C. H.;Rockland, Kathleen S.;Rossier, Jean;Rudy, Bernardo;Somogyi, Peter;Staiger, Jochen F.;Tamas, Gabor;Thomson, Alex M.;Toledo-Rodriguez, Maria;Wang, Yun;West, David C.;Yuste, Rafael
通讯作者：
Yuste, Rafael