Rapid synthesis of drug-encapsulated films by evaporation-induced self-assembly for highly-controlled drug release from biomaterial surfaces.
Rapid synthesis of drug-encapsulated films by evaporation-induced self-assembly for highly-controlled drug release from biomaterial surfaces.
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通过蒸发诱导的自组装从生物材料表面释放高度控制的药物，快速合成药物包容的膜。
DOI：
10.1039/d1tb02121d
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发表时间：
2022-08-31
影响因子：
7
通讯作者：
Hatton, B.
中科院分区：
文献类型：
--
作者：
Stewart, C.;Siu, A.;Tsui, C.;Finer, Y.;Hatton, B.
种植牙手术部位的感染会导致手术失败、患者疼痛、沉重的经济影响以及预防性抗生素的过度处方。介孔二氧化硅膜作为植入物的涂层可以提供理想的抗微生物药物储存和局部释放载体到感染部位，然而传统的载药技术导致载药量不足和短期释放动力学。在这项工作中，我们已经应用了一种方法，使用表面活性剂，抗菌药物奥替尼啶盐酸盐（OCT）作为模板的介孔结构的二氧化硅，以证明二氧化硅OCT复合膜。薄膜的蒸发诱导自组装（EISA）合成，我们探讨了多孔膜结构，OCT掺入，OCT药物释放速率的合成参数的影响。药物胶束掺入二氧化硅介观结构高度依赖于二氧化硅前体预反应，以形成二氧化硅低聚物之前，薄膜旋涂。合成溶液的OCT药物浓度决定了有效掺入（无相分离）所需的时间，膜中的总负载量高达90%（质量）。发现膜中的OCT含量直接决定药物释放的时间尺度，对于单层膜为2至8小时。通过添加多层OCT-二氧化硅膜，总释放时间增加至近2周。药物从薄膜中释放完全抑制变形链球菌（UA 159）的生长，而无药物的多孔二氧化硅薄膜没有显示出增加细菌的生长超过非多孔控制。这些OCT-二氧化硅膜具有储存和从牙种植体表面释放抗微生物药物的显著潜力。
Infection at the surgical site for dental implants results in failed procedures, patient pain, burdensome economic impact, and the over-prescription of prophylactic antibiotics. Mesoporous silica films as coatings for implants may provide an ideal antimicrobial drug storage and local release vector to the site of infection, however traditional drug loading techniques result in insufficient drug load and short-term release kinetics. In this work, we have applied a method to use a surfactant-antimicrobial drug octenidine dihydrochloride (OCT) as a template for mesostructured silica, to demonstrate silica-OCT composite films. The films are synthesized by evaporation induced self-assembly (EISA) and we explore the effects of synthesis parameters on porous film structure, OCT incorporation, and OCT drug release rates. Drug micelle incorporation into the silica mesostructure was highly dependent on silica precursor pre-reaction to form silica oligomers before film spin-casting. The OCT drug concentration of the synthesis solution dictated the time required for effective incorporation (without phase separation), with total loading in the film of up to 90 % by mass. The OCT content in the films was found to directly determine the timescale of drug release, from 2 to 8 h for a single layer film. The total release timescale was increased by the addition of multiple layers of OCT-silica films to nearly 2 weeks. Drug release from films completely inhibited Streptococcus mutans (UA159) growth, while drug-free porous silica films showed no increase in bacterial growth over non-porous control. These OCT-silica films have a significant potential to store and release antimicrobial drugs from dental implant surfaces.
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影响因子：
19
作者：
Grosso, D;Cagnol, F;Sanchez, C
通讯作者：
Sanchez, C
影响因子：
1.7
作者：
Costerton, JW;Montanaro, L;Arciola, CR
通讯作者：
Arciola, CR
影响因子：
8.6
作者：
Fontecave, Thomas;Boissiere, Cedric;Sanchez, Clement
通讯作者：
Sanchez, Clement
影响因子：
--
作者：
Belongia, EA;Schwartz, B
通讯作者：
Schwartz, B
影响因子：
4.3
作者：
Giret, Simon;Man, Michel Wong Chi;Carcel, Carole
通讯作者：
Carcel, Carole