Classification and Antigen Molecules of Autoimmune Bullous Diseases.

Classification and Antigen Molecules of Autoimmune Bullous Diseases.
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自身免疫性大胆疾病的分类和抗原分子。

DOI:
10.3390/biom13040703
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发表时间:
2023-04-20
期刊:
影响因子:
5.5
通讯作者:
--
中科院分区:
生物学2区
文献类型:
--
作者:

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自身免疫性大疱病(Autoimmune bullous diseases,AIBD)是一组组织特异性自身免疫性皮肤病,表现为皮肤和粘膜上的各种水疱性病变,并出现抗表皮细胞表面和基底膜带的IgG、伊加和IgM等自身抗体。迄今为止,AIBD已根据临床和组织病理学表现以及免疫学特征分为许多不同的亚型。此外,各种生物化学和分子生物学研究已经在AIBD中发现了各种新型自身抗原,从而提出了AIBD的新亚型。本文综述了各种不同的AIBD,并提出了最新、最全面的AIBD分类及其自身抗原分子。
Autoimmune bullous diseases (AIBDs), which are a group of tissue-specific autoimmune diseases of the skin, present with various blistering lesions on the skin and mucous membranes, and show autoantibodies of IgG, IgA and IgM against epidermal cell surfaces and basement membrane zone. To date, AIBDs have been classified into a number of distinct subtypes by clinical and histopathological findings, and immunological characteristics. In addition, various biochemical and molecular biological studies have identified various novel autoantigens in AIBDs, which has resulted in proposals of new subtypes of AIBDs. In this article, we summarized various distinct AIBDs, and proposed the latest and most comprehensive classification of AIBDs with their autoantigen molecules.
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