Fabrication of paper-based microfluidic devices using a 3D printer and a commercially-available wax filament
Fabrication of paper-based microfluidic devices using a 3D printer and a commercially-available wax filament
复制标题
使用 3D 打印机和市售蜡丝制造纸基微流体装置
DOI：
10.1016/j.talo.2022.100142
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Cunci, Lisandro
中科院分区：
文献类型：
--
作者：
Espinosa, Antonio;Diaz, Joannes;Vazquez, Edgar;Acosta, Lina;Santiago, Arianna;Cunci, Lisandro
在这项工作中，我们开发了一种通过3D打印和蜡丝制造纸基微流体的替代方法。微流控纸基分析设备（µ PAD）是用于各种化学和生物分析和研究的低成本且易于制造的工具。由于制造商已经停止了大多数蜡打印设备，因此具有蜡的纸基微流体受到限制。我们的目标是开发一种低成本和可访问的制造方法，可以取代传统的蜡纸基微流体制造方法。使用高度可用的商业3D打印技术和蜡丝，我们可以在不同纸张类型的表面上创建疏水蜡屏障。对该生产方法的性能和限度进行了表征。此外，使用这种基于纸张的微流体制造方法，我们能够使用µPAD作为基于被动流动的方法以电化学方式测量多巴胺，浓度低至1 nM，注射量小至15 µL。
In this work, we developed an alternative manufacturing paper-based microfluidics method through 3D printing and wax filament. Microfluidic paper-based analytical devices (µPADs) are low-cost and easy-to-manufacture tools used for various chemical and biological analyses and studies. Paper-based microfluidics with wax has been limited as the manufacturers have discontinued most wax printing equipment. We aim to develop a low-cost and accessible manufacturing method that can replace conventional wax-on paper-based microfluidic manufacturing methods. Using highly available commercial 3D printing technology and wax filament, we could create hydrophobic wax barriers on the surface of different paper types. The properties and limits of this manufacturing method were characterized. Moreover, using this paper-based microfluidic manufacturing method, we were able to measure dopamine electrochemically using µPAD as a passive flow-based method in concentrations as low as 1 nM using injections as small as 15 µL.
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影响因子：
6.1
作者：
Nie Z;Nijhuis CA;Gong J;Chen X;Kumachev A;Martinez AW;Narovlyansky M;Whitesides GM
通讯作者：
Whitesides GM
影响因子：
8.4
作者：
Juang, Yi-Je;Chen, Po-Sheng;Wang, Yu
通讯作者：
Wang, Yu
影响因子：
7.4
作者：
Rivera-Serrano N;Pagan M;Colón-Rodríguez J;Fuster C;Vélez R;Almodovar-Faria J;Jiménez-Rivera C;Cunci L
通讯作者：
Cunci L
影响因子：
6.1
作者：
Channon RB;Nguyen MP;Scorzelli AG;Henry EM;Volckens J;Dandy DS;Henry CS
通讯作者：
Henry CS