Rapid flow in multilayer microfluidic paper-based analytical devices.
Rapid flow in multilayer microfluidic paper-based analytical devices.
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DOI：
10.1039/c7lc01300k
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发表时间：
2018-02-27
期刊：
影响因子：
6.1
通讯作者：
Henry CS
中科院分区：
文献类型：
--
作者：
Channon RB;Nguyen MP;Scorzelli AG;Henry EM;Volckens J;Dandy DS;Henry CS
微流控纸基分析装置 (μPAD) 是一种多功能且廉价的即时护理 (POC) 技术，但其广泛采用受到流速慢和无法进行复杂的现场分析测量的限制。在目前的工作中，我们研究多层 μPAD 作为在自泵纸装置中产生增强流速的一种手段。通过光学和电化学测量，研究流体动力学并与 μPAD 内已建立的流动理论进行比较。与典型的 1 层 μPAD 设计相比，通过精确控制 2 层纸器件中的通道高度，我们证明了流速增加了约 145 倍（速度 = 1.56 cm s−1，体积流速 = 1.65 mL min−1，超过 5.5 cm）。然后将这些设计考虑应用于自泵顺序注射装置格式，称为三维纸网络（3DPN）。这些 3DPN 器件通过二茂铁络合物的流动注射分析和镉的阳极剥离检测来表征，与静态测量相比，信号增强了 5 倍。
Microfluidic paper-based analytical devices (μPADs) are a versatile and inexpensive point-of-care (POC) technology, but their widespread adoption has been limited by slow flow rates and the inability to carry out complex in field analytical measurements. In the present work, we investigate multilayer μPADs as a means to generate enhanced flow rates within self-pumping paper devices. Through optical and electrochemical measurements, the fluid dynamics are investigated and compared to established flow theories within μPADs. We demonstrate a ~145-fold increase in flow rate (velocity = 1.56 cm s−1, volumetric flow rate = 1.65 mL min−1, over 5.5 cm) through precise control of the channel height in a 2 layer paper device, as compared to archetypical 1 layer μPAD designs. These design considerations are then applied to a self-pumping sequential injection device format, known as a three-dimensional paper network (3DPN). These 3DPN devices are characterized through flow injection analysis of a ferrocene complex and anodic stripping detection of cadmium, exhibiting a 5× enhancement in signal compared to stationary measurements.
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