Transcranial direct current stimulation (tDCS) in depression induces structural plasticity.
Transcranial direct current stimulation (tDCS) in depression induces structural plasticity.
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经颅直流电刺激（tDCS）可诱导抑郁症患者的结构可塑性。
DOI：
10.1038/s41598-023-29792-6
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发表时间：
2023-02-17
影响因子：
4.6
通讯作者：
Narr, Katherine
中科院分区：
文献类型：
--
作者：
Jog, Mayank A.;Anderson, Cole;Kubicki, Antoni;Boucher, Michael;Leaver, Amber;Hellemann, Gerhard;Iacoboni, Marco;Woods, Roger;Narr, Katherine
经颅直流电刺激（tDCS）是一种非侵入性神经调节技术，涉及通过头皮电极向大脑输送耐受性良好的电流。TDCS可能会改善神经精神疾病的症状，但最近的临床试验的混合结果强调，需要证明tDCS可以随着时间的推移调节患者的临床相关脑系统。在这里，我们分析了纵向结构MRI数据从随机，双盲，平行设计的临床试验抑郁症（NCT 03556124，N = 59），以调查是否连续tDCS单独针对左背外侧前额叶皮层（DLPFC）可以诱导神经结构的变化。在左侧DLPFC刺激靶点内，相对于假tDCS，使用活性高清（HD）tDCS观察到显著（FWEc p < 0.05）治疗相关灰质变化。活性传统tDCS未观察到变化。个体治疗组内的随访分析显示，在与刺激靶点功能相关的脑区中，活动性HD-tDCS的灰质显著增加，包括双侧DLPFC、双侧后扣带皮层、膝下前扣带皮层以及右侧海马、丘脑和左侧尾状脑区。验证了设盲的完整性，未观察到治疗组之间刺激相关不适的显著差异，并且未通过任何其他辅助治疗增强tDCS治疗。总的来说，这些结果表明，串行HD-tDCS导致神经结构的变化在一个预先确定的大脑目标抑郁症，并表明这种可塑性的影响可能会传播大脑网络。
Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique involving administration of well-tolerated electrical current to the brain through scalp electrodes. TDCS may improve symptoms in neuropsychiatric disorders, but mixed results from recent clinical trials underscore the need to demonstrate that tDCS can modulate clinically relevant brain systems over time in patients. Here, we analyzed longitudinal structural MRI data from a randomized, double-blind, parallel-design clinical trial in depression (NCT03556124, N = 59) to investigate whether serial tDCS individually targeted to the left dorso-lateral prefrontal cortex (DLPFC) can induce neurostructural changes. Significant (FWEc p < 0.05) treatment-related gray matter changes were observed with active high-definition (HD) tDCS relative to sham tDCS within the left DLPFC stimulation target. No changes were observed with active conventional tDCS. A follow-up analysis within individual treatment groups revealed significant gray matter increases with active HD-tDCS in brain regions functionally connected with the stimulation target, including the bilateral DLPFC, bilateral posterior cingulate cortex, subgenual anterior cingulate cortex, and the right hippocampus, thalamus and left caudate brain regions. Integrity of blinding was verified, no significant differences in stimulation-related discomfort were observed between treatment groups, and tDCS treatments were not augmented by any other adjunct treatments. Overall, these results demonstrate that serial HD-tDCS leads to neurostructural changes at a predetermined brain target in depression and suggest that such plasticity effects may propagate over brain networks.
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MI-BCI训练后的大脑可塑性与TDC在慢性皮质下卒中受试者的随机试验中结合使用：初步研究。
影响因子：
4.6
作者：
Hong X;Lu ZK;Teh I;Nasrallah FA;Teo WP;Ang KK;Phua KS;Guan C;Chew E;Chuang KH
通讯作者：
Chuang KH
影响因子：
6.8
作者：
Jog MS;Kim E;Anderson C;Kubicki A;Kayathi R;Jann K;Yan L;Leaver A;Hellemann G;Iacoboni M;Woods RP;Wang DJJ;Narr KL
通讯作者：
Narr KL
DOI：
10.1016/j.pnpbp.2011.09.014
发表时间：
2012-01-10
影响因子：
5.6
作者：
Du, Ming-Ying;Wu, Qi-Zhu;Gong, Qi-Yong
通讯作者：
Gong, Qi-Yong
DOI：
10.1073/pnas.1405003111
发表时间：
2014-10-14
影响因子：
11.1
作者：
Fox, Michael D.;Buckner, Randy L.;Pascual-Leone, Alvaro
通讯作者：
Pascual-Leone, Alvaro
影响因子：
3.3
作者：
Drevets, Wayne C.;Savitz, Jonathan
通讯作者：
Savitz, Jonathan