Brain plasticity following MI-BCI training combined with tDCS in a randomized trial in chronic subcortical stroke subjects: a preliminary study.
Brain plasticity following MI-BCI training combined with tDCS in a randomized trial in chronic subcortical stroke subjects: a preliminary study.
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MI-BCI训练后的大脑可塑性与TDC在慢性皮质下卒中受试者的随机试验中结合使用：初步研究。
DOI：
10.1038/s41598-017-08928-5
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发表时间：
2017-08-23
影响因子：
4.6
通讯作者：
Chuang KH
中科院分区：
文献类型：
--
作者：
Hong X;Lu ZK;Teh I;Nasrallah FA;Teo WP;Ang KK;Phua KS;Guan C;Chew E;Chuang KH
脑-计算机接口辅助运动想象（MI-BCI）或经颅直流电刺激（tDCS）已被用于中风康复，尽管它们的组合效果尚不清楚。我们研究了在单侧上肢残疾的慢性皮质下卒中患者中进行MI-BCI和tDCS联合干预后的脑可塑性。19例患者随机分为tDCS组和假tDCS组。分别在2周干预前和干预后4周，采用弥散和灌注MRI以及经颅磁刺激研究结构连接性、脑血流量（CBF）和皮质脊髓兴奋性。质量控制后，13名受试者被纳入CBF分析。11名健康对照者接受了2次MRI检查，以进行再现性研究。而运动表现表现出相当的改善，持久的神经可塑性只能在tDCS组中检测到，其中在病灶侧皮质脊髓束和双侧胼胝体中的白色物质完整性增加，但感觉运动CBF减少，特别是在病灶侧。双侧顶叶皮质的CBF变化也与运动功能改善相关，与连接这些区域的胼胝体中白色物质完整性增加一致，表明参与了半球间的相互作用。初步结果表明，tDCS可以促进神经可塑性，并建议改善中风患者的康复策略的潜力。
Brain-computer interface-assisted motor imagery (MI-BCI) or transcranial direct current stimulation (tDCS) has been used in stroke rehabilitation, though their combinatory effect is unknown. We investigated brain plasticity following a combined MI-BCI and tDCS intervention in chronic subcortical stroke patients with unilateral upper limb disability. Nineteen patients were randomized into tDCS and sham-tDCS groups. Diffusion and perfusion MRI, and transcranial magnetic stimulation were used to study structural connectivity, cerebral blood flow (CBF), and corticospinal excitability, respectively, before and 4 weeks after the 2-week intervention. After quality control, thirteen subjects were included in the CBF analysis. Eleven healthy controls underwent 2 sessions of MRI for reproducibility study. Whereas motor performance showed comparable improvement, long-lasting neuroplasticity can only be detected in the tDCS group, where white matter integrity in the ipsilesional corticospinal tract and bilateral corpus callosum was increased but sensorimotor CBF was decreased, particularly in the ipsilesional side. CBF change in the bilateral parietal cortices also correlated with motor function improvement, consistent with the increased white matter integrity in the corpus callosum connecting these regions, suggesting an involvement of interhemispheric interaction. The preliminary results indicate that tDCS may facilitate neuroplasticity and suggest the potential for refining rehabilitation strategies for stroke patients.
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DOI：
10.1016/j.apmr.2014.08.008
发表时间：
2015-03-01
影响因子：
4.3
作者：
Ang, Kai Keng;Guan, Cuntai;Chew, Effie
通讯作者：
Chew, Effie
影响因子：
8.3
作者：
Celnik, Pablo;Paik, Nam-Jong;Cohen, Leonardo G.
通讯作者：
Cohen, Leonardo G.
影响因子：
1.7
作者：
Fregni, F;Boggio, PS;Pascual-Leone, A
通讯作者：
Pascual-Leone, A
DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
影响因子：
6.6
作者：
Boggio, Paulo S.;Bermpohl, Felix;Fregni, Felipe
通讯作者：
Fregni, Felipe