TNF-α and IL-6 are associated with the deficit syndrome and negative symptoms in patients with chronic schizophrenia.
TNF-α and IL-6 are associated with the deficit syndrome and negative symptoms in patients with chronic schizophrenia.
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DOI：
10.1016/j.schres.2018.02.048
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发表时间：
2018-09
影响因子：
4.5
通讯作者：
Miller BJ
中科院分区：
文献类型：
--
作者：
Goldsmith DR;Haroon E;Miller AH;Strauss GP;Buckley PF;Miller BJ
在慢性精神分裂症患者中发现炎症标志物增加，并与阴性症状相关。缺陷综合征是精神分裂症的一种独特亚型，以原发性和持久性阴性症状为特征。我们测量了有和没有缺陷的精神分裂症患者和对照组的炎症标志物。使用多变量分析，肿瘤坏死因子（TNF）-α和白细胞介素-6与缺陷综合征相关，而TNF-α预测情感迟钝、失语和完全阴性症状。研究结果表明，缺陷型精神分裂症亚型与炎症增加有关，免疫疗法可能是阴性症状的新靶点。
Increased inflammatory markers have been found in patients with chronic schizophrenia, and have been associated with negative symptoms. The deficit syndrome is a distinct subtype of schizophrenia, characterized by primary and enduring negative symptoms. We measured inflammatory markers in patients with and without deficit schizophrenia and controls. Using multivariate analyses, tumor necrosis factor (TNF)-α and interleukin-6 were associated with the deficit syndrome, and TNF-α predicted blunted affect, alogia, and total negative symptoms. Findings suggest that deficit schizophrenia subtype is associated with increased inflammation and immunotherapies may be a novel target for negative symptoms.
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