Higher n-3 fatty acids are associated with more intense fenfluramine-induced ACTH and cortisol responses among cocaine-abusing men.
Higher n-3 fatty acids are associated with more intense fenfluramine-induced ACTH and cortisol responses among cocaine-abusing men.
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DOI：
10.1016/j.psychres.2011.05.027
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发表时间：
2011-08-15
影响因子：
11.3
通讯作者：
Hibbeln, Joseph R.
中科院分区：
文献类型：
--
作者：
Buydens-Branchey, Laure;Branchey, Marc;Hibbeln, Joseph R.
临床前研究表明，补充或缺乏n-3多不饱和脂肪酸（PUFA）的饮食可能会影响多巴胺能神经传递，但有关其对人类多巴胺能功能影响的信息很少。因此，在25名可卡因滥用男性和12名对照受试者中同时评估了n-3 PUFAs和ACTH和皮质醇对5-羟色胺（5-HT）探针，d，l-芬氟拉明（FEN）挑战的反应。可卡因滥用者在进入封闭病房18天后接受检测。在随机给予60 mg FEN或安慰剂后48小时间隔的2个试验日收集的血浆样本中测量ACTH和皮质醇。在第一个测试日样品中测量脂肪酸。患者的FEN诱导的ACTH升高与二十二碳六烯酸（DHA）和二十碳五烯酸（EPA）显著正相关。患者的皮质醇升高与EPA呈正相关，但与DHA无关。激素反应和住院前可卡因使用参数之间没有显着的相关性。对照组受试者对FEN的反应与任何PUFA无关。总之，较高的EPA和DHA水平与更强烈的FEN诱导的ACTH反应和更高的EPA水平与更强烈的皮质醇反应在可卡因滥用的男子退出可卡因，但不是在控制对象。这些发现支持并扩展了现有的证据，即EPA和DHA可以影响某些人类亚群的5-HT功能。
Preclinical studies have shown that diets supplemented with or deficient in n-3 polyunsaturated fatty acids (PUFAs) could influence serotonergic neurotransmission but information about their effects on the serotonergic function of humans is scant. Therefore simultaneous assessments of n-3 PUFAs and of the ACTH and cortisol responses to challenges with the serotonin (5-HT) probe, d,l-fenfluramine (FEN) were performed in 25 cocaine abusing men and 12 control subjects. Cocaine abusers were tested 18 days after their admission to a closed ward. ACTH and cortisol were measured in plasma samples collected on 2 testing days separated by 48 hours following the random administration of 60 mg of FEN or placebo. Fatty acids were measured in the first test day samples. Patients’ FEN-induced ACTH rises were significantly and positively correlated with docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Patients’ cortisol rises were positively and significantly correlated with EPA but not with DHA. There were no significant correlations between hormonal responses and pre-hospitalization cocaine use parameters. Control subjects’ responses to FEN were not correlated with any PUFA. In conclusion, higher EPA and DHA levels were associated with a more intense FEN-induced ACTH response and higher EPA levels with a more intense cortisol response in cocaine abusing men withdrawn from cocaine but not in control subjects. These findings support and expand existing evidence that EPA and DHA could influence 5-HT function in some human subgroups.
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影响因子：
4.1
作者：
Contoreggi, C;Herning, RI;Hess, J
通讯作者：
Hess, J
影响因子：
4.2
作者：
Ghitza, Udi E.;Rothman, Richard B.;Baumann, Michael H.
通讯作者：
Baumann, Michael H.
影响因子：
3.6
作者：
Owens, SD;Innis, SM
通讯作者：
Innis, SM
DOI：
10.1037/h0046900
发表时间：
1957-01-01
期刊：
JOURNAL OF CONSULTING PSYCHOLOGY
影响因子：
--
作者：
BUSS, AH;DURKEE, A
通讯作者：
DURKEE, A
影响因子：
6.5
作者：
Masood, A;Stark, KD;Salem, N
通讯作者：
Salem, N