A Regulatory Response to Ribosomal Protein Mutations Controls Translation, Growth, and Cell Competition.
A Regulatory Response to Ribosomal Protein Mutations Controls Translation, Growth, and Cell Competition.
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DOI：
10.1016/j.devcel.2018.07.003
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发表时间：
2018-08-20
影响因子：
11.8
通讯作者：
Baker NE
中科院分区：
文献类型：
--
作者：
Lee CH;Kiparaki M;Blanco J;Folgado V;Ji Z;Kumar A;Rimesso G;Baker NE
核糖体执行蛋白质合成，但也参与了信号传导过程，我们的全部范围仍在发现，我们报告了突变的核糖体蛋白（RP）的表型，这在很大程度上是由于信号造成的。引起RP的细胞竞争遗传镶嵌物的杂合细胞，即使是RP基因的均质细胞，RP突变细胞中的XRP1持续存在。生产限制蛋白质合成。
某些突变细胞仅在Mosaic组织中消除。
Ribosomes perform protein synthesis but are also involved in signaling processes, the full extent of which are still being uncovered. We report that phenotypes of mutating ribosomal proteins (Rp’s) are largely due to signaling. Using Drosophila, we discovered that a bZip-domain protein Xrp1 becomes elevated in Rp mutant cells. Xrp1 reduces translation and growth, delays development, is responsible for gene expression changes, and causes the cell competition of Rp heterozygous cells from genetic mosaics. Without Xrp1, even cells homozygously-deleted for Rp genes persist and grow. Xrp1 induction in Rp mutant cells depends on a particular Rp with regulatory effects, RpS12, and precedes overall changes in translation. Thus effects of Rp mutations, even the reduction in translation and growth, depend on signaling through the Xrp1 pathway and are not simply consequences of reduced ribosome production limiting protein synthesis. One benefit of this system may be to eliminate Rp-mutant cells by cell competition. Certain mutant cells are eliminated only in mosaic tissues. Lee et al. isolate mutations in a bZip domain protein, Xrp1, that rescue ribosomal protein (Rp) heterozygous mutant cells from such competition. Xrp1 accounts for many aspects of the Rp mutant phenotype, indicating they are not direct consequences of ribosome depletion.
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影响因子：
56.9
作者：
GOLIC, KG
通讯作者：
GOLIC, KG
影响因子：
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作者：
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作者：
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