The prevalence of hearing impairment and associated risk factors: the Beaver Dam Offspring Study.
The prevalence of hearing impairment and associated risk factors: the Beaver Dam Offspring Study.
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DOI：
10.1001/archoto.2011.15
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发表时间：
2011-05
影响因子：
--
通讯作者：
Tweed, Theodore S.
中科院分区：
文献类型：
--
作者：
Nash, Scott D.;Cruickshanks, Karen J.;Klein, Ronald;Klein, Barbara E. K.;Nieto, F. Javier;Huang, Guan H.;Pankow, James S.;Tweed, Theodore S.
评估中年成年人听力损伤（HI）的患病率，并评估环境和心血管疾病风险因素与听力损伤之间的横断面关联。
数据是作为海狸坝后代研究（BOSS）的一部分收集的，这是一项关于衰老的流行病学队列研究。听力损伤定义为任一只耳在0.5、1、2、4kHz的纯音平均听阈（PTA）>25分贝听力级。采用西北大学6号单词表测量竞争信息中的单词识别能力（WRCM）。收集了有关行为、环境因素和病史的问卷调查信息。
参与者（n = 3285）是基于人群的听力损失流行病学研究参与者的后代，年龄在21 - 84岁之间（平均年龄 = 49岁）。
听力损伤的患病率为14.1%，WRCM得分的中位数为64%（标准差 = 15%）。在一个多变量模型中，在控制年龄、性别、教育程度和职业噪声后，耳部手术史（比值比（OR）= 4.11，95%置信区间（CI）= 2.37，7.15）、较大的视网膜中央静脉等效直径（CRVE）（OR = 1.77，95%CI = 1.20，2.60；第4四分位数与第1四分位数相比）以及较高的血细胞比容百分比（OR = 0.77，95%CI = 0.63，0.95；每5%）与听力损伤独立相关。与较低WRCM得分相关的因素类似，但还包括平均内膜 - 中膜厚度（平均差异 = -0.63%（-1.06，-0.19），P = 0.005；每0.1mm）和他汀类药物的使用（平均差异 = -2.09%（-3.58，-0.60），P = 0.005）。
听力损伤是中年成年人的一种常见疾病。心血管疾病风险因素可能是年龄相关性听觉功能障碍的重要相关因素。
To estimate the prevalence of hearing impairment (HI) and evaluate the cross-sectional associations of environmental and cardiovascular disease risk factors and HI in middle-aged adults. Data were collected as part of the Beaver Dam Offspring Study (BOSS), an epidemiological cohort study of aging. HI was defined as a pure-tone average (PTA) 0.5,1,2,4kHz >25 db HL in either ear. Word recognition in competing message (WRCM) was measured using the Northwestern University #6 word list. Questionnaire information about behaviors, environmental factors and medical history was collected. Participants (n=3,285) were offspring of participants of the population-based Epidemiology of Hearing Loss Study, and ranged in age from 21–84 years (mean age=49 years). The prevalence of HI was 14.1%, and the median WRCM score was 64% (standard deviation=15%). In a multivariate model, controlling for age, sex, education, and occupational noise, a history of ear surgery (Odds Ratio (OR) = 4.11, 95%Confidence Interval (CI) = 2.37, 7.15), larger central retinal venular equivalent (CRVE) (OR = 1.77, 95%CI = 1.20, 2.60; 4th q vs. 1st q), and higher hematocrit percentage (OR = 0.77, 95% CI = 0.63, 0.95; per 5%) were independently associated with HI. Factors associated with lower WRCM scores were similar but also included mean intima-media thickness (mean difference= −0.63% (−1.06, −0.19) P= 0.005; per 0.1mm) and statin use (mean difference= −2.09% (−3.58, −0.60) P=0.005). HI is a common condition in middle-aged adults. CVD risk factors may be important correlates of age-related auditory dysfunction.
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