Anterior and posterior cingulate cortex volume in healthy adults: effects of aging and gender differences.
Anterior and posterior cingulate cortex volume in healthy adults: effects of aging and gender differences.
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DOI：
10.1016/j.brainres.2011.05.050
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发表时间：
2011-07-15
期刊：
影响因子：
2.9
通讯作者：
Chu KW
中科院分区：
文献类型：
--
作者：
Mann SL;Hazlett EA;Byne W;Hof PR;Buchsbaum MS;Cohen BH;Goldstein KE;Haznedar MM;Mitsis EM;Siever LJ;Chu KW
扣带皮层经常表现出随着年龄的增长以及结构和功能的性别差异的灰质损失，但很少有人知道是否个别扣带布罗德曼地区显示与年龄相关的体积下降的性别特异性模式。这项研究探讨了年龄相关的变化，性别差异，以及年龄和性别的相互作用，在区域25，24，31，23和29，超过70年的成年扣带灰质的相对体积。参与者包括健康、年龄匹配的男性和女性，年龄在20-87岁之间（n = 70）。结果表明：（1）扣带回整体体积随年龄增长而下降（20 ~ 80岁平均下降5.54%）;五个扣带回区域中的每一个都随着年龄的增长而显着下降，并且各个区域在几十年内表现出不同的下降模式：随着年龄的增长，体积较小在31区最明显，其次是25和24。(2)女性扣带回灰质体积比男性整体和24区相对较大。(3)男性和女性在中年和晚年的31区表现出不同的年龄相关体积下降模式。通过描绘正常的性别差异和年龄相关的形态学变化在扣带皮层超过70年的成年期，本研究提高了基线比较与结构不规则的扣带皮层与精神病理学。Brodmann面积为基础的方法也有利于跨研究的比较，旨在得出扣带回的年龄和性别相关的结构差异和相应的扣带回功能的差异之间的推论。
The cingulate cortex frequently shows gray matter loss with age as well as gender differences in structure and function, but little is known about whether individual cingulate Brodmann areas show gender-specific patterns of age-related volume decline. This study examined age-related changes, gender differences, and the interaction of age and gender in the relative volume of cingulate gray matter in areas 25, 24, 31, 23, and 29, over seven decades of adulthood. Participants included healthy, age-matched men and women, aged 20–87 (n = 70). Main findings were: (1) The whole cingulate showed significant age-related volume declines (averaging 5.54% decline between decades, 20s–80s). Each of the five cingulate areas also showed a significant decline with age, and individual areas showed different patterns of decline across the decades: Smaller volume with age was most evident in area 31, followed by 25 and 24. (2) Women had relatively larger cingulate gray matter volume than men overall and in area 24. (3) Men and women showed different patterns of age-related volume decline in area 31, at midlife and late in life. By delineating normal gender differences and age-related morphometric changes in the cingulate cortex over seven decades of adulthood, this study improves the baseline for comparison with structural irregularities in the cingulate cortex associated with psychopathology. The Brodmann area-based approach also facilitates comparisons across studies that aim to draw inferences between age- and gender-related structural differences in the cingulate gyrus and corresponding differences in cingulate function.
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影响因子：
4.5
作者：
Buchsbaum, MS;Hazlett, EA
通讯作者：
Hazlett, EA
DOI：
10.1523/jneurosci.3021-09.2010
发表时间：
2010-01-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Goldstein JM;Jerram M;Abbs B;Whitfield-Gabrieli S;Makris N
通讯作者：
Makris N
影响因子：
3.2
作者：
Grady, CL;Springer, MV;Winocur, G
通讯作者：
Winocur, G
影响因子：
4.2
作者：
Hazlett, Erin A.;Byne, William;Buchsbaum, Monte S.
通讯作者：
Buchsbaum, Monte S.
影响因子：
4.8
作者：
Butler, Tracy;Imperato-McGinley, Julianne;Silbersweig, David
通讯作者：
Silbersweig, David