Real-World Evaluation of Direct and Indirect Economic Burden Among Endometriosis Patients in the United States.
Real-World Evaluation of Direct and Indirect Economic Burden Among Endometriosis Patients in the United States.
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DOI：
10.1007/s12325-018-0667-3
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发表时间：
2018-03
影响因子：
3.8
通讯作者：
Castelli-Haley J
中科院分区：
文献类型：
--
作者：
Soliman AM;Surrey E;Bonafede M;Nelson JK;Castelli-Haley J
子宫内膜异位症的患病率和治疗的需要在美国导致需要探索与疾病相关的当代成本负担。这项回顾性队列研究比较了子宫内膜异位症患者与对照组（无子宫内膜异位症）的直接和间接医疗费用。在2010年至2014年期间，在Truven Health MarketScan®商业数据库中确定了18-49岁的子宫内膜异位症女性（初次诊断日期=索引日期），并按年龄和索引年匹配了未患子宫内膜异位症的女性对照患者。比较了以下结局：指数前和指数后12个月期间的医疗保健资源利用（HRU）（包括住院、药房报销、急诊室就诊、医生办公室就诊和产科/妇科就诊），（医药）和间接（缺勤、短期残疾和长期残疾）指数发布后12个月期间的医疗保健费用（以2014年美元计）。进行多变量分析，以估计年度总直接和间接成本，控制人口统计学，索引前临床特征和索引前医疗保健成本。总体而言，包括113，506名子宫内膜异位症患者和927，599名对照。与对照组相比，子宫内膜异位症患者在索引前和索引后的HRU均显著较高（p < 0.0001，所有HRU类别）。大约三分之二的子宫内膜异位症患者在指数后的前12个月内接受了子宫内膜异位症相关的外科手术（包括剖腹手术、腹腔镜手术、子宫切除术、卵巢切除术和其他切除/消融术）。在指数后12个月期间，每位子宫内膜异位症患者的平均年总调整直接成本是非子宫内膜异位症对照组的3倍多[16，573美元（标准差（SD）= 21，336美元）vs. 4733美元（SD = 14，833美元）; p < 0.005]。平均而言，每位子宫内膜异位症患者12个月的直接和间接成本分别为10，002美元和2132美元（p < 0.005）。子宫内膜异位症患者的直接和间接医疗费用明显高于非子宫内膜异位症患者。AbbVie Inc.本文的在线版本（10.1007/s12325-018-0667-3）包含补充材料，可供授权用户使用。
The prevalence of endometriosis and the need for treatment in the USA has led to the need to explore the contemporary cost burden associated with the disease. This retrospective cohort study compared direct and indirect healthcare costs in patients with endometriosis to a control group without endometriosis. Women aged 18–49 years with endometriosis (date of initial diagnosis = index date) were identified in the Truven Health MarketScan® Commercial database between 2010 and 2014 and female control patients without endometriosis were matched by age and index year. The following outcomes were compared: healthcare resource utilization (HRU) during the 12-month pre- and post-index periods (including inpatient admissions, pharmacy claims, emergency room visits, physician office visits, and obstetrics/gynecology visits), annual direct (medical and pharmacy) and indirect (absenteeism, short-term disability, and long-term disability) healthcare costs during the 12-month post-index period (in 2014 US$). Multivariate analyses were conducted to estimate annual total direct and indirect costs, controlling for demographics, pre-index clinical characteristics, and pre-index healthcare costs. Overall, 113,506 endometriosis patients and 927,599 controls were included. Endometriosis patients had significantly higher HRU during both the pre- and post-index periods compared to controls (p < 0.0001, all categories of HRU). Approximately two-thirds of endometriosis patients underwent an endometriosis-related surgical procedure (including laparotomy, laparoscopy, hysterectomy, oophorectomy, and other excision/ablation procedures) in the first 12 months post-index. Mean annual total adjusted direct costs per endometriosis patient during the 12-month post-index period was over three times higher than that for a non-endometriosis control [$16,573 (standard deviation (SD) = $21,336) vs. $4733 (SD = $14,833); p < 0.005]. On average, incremental direct and indirect 12-month costs per endometriosis patient were $10,002 and $2132 compared to their matched controls (p < 0.005). Endometriosis patients incurred significantly higher direct and indirect healthcare costs than non-endometriosis patients. AbbVie Inc. The online version of this article (10.1007/s12325-018-0667-3) contains supplementary material, which is available to authorized users.
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影响因子：
2.4
作者：
Fuldeore, M;Chwalisz, K;Lamothe, K
通讯作者：
Lamothe, K
影响因子：
6.7
作者：
Nnoaham, Kelechi E.;Hummelshoj, Lone;Webster, Premila;d'Hooghe, Thomas;Nardone, Fiorenzo de Cicco;Nardone, Carlo de Cicco;Jenkinson, Crispin;Kennedy, Stephen H.;Zondervan, Krina T.
通讯作者：
Zondervan, Krina T.
影响因子：
2.1
作者：
Soliman, Ahmed M.;Coyne, Karin S.;Surrey, Eric S.
通讯作者：
Surrey, Eric S.
影响因子：
6.7
作者：
Burney, Richard O.;Giudice, Linda C.
通讯作者：
Giudice, Linda C.
影响因子：
3.5
作者：
Jensen, Jeffrey T.;Lefebvre, Patrick;Duh, Mei Sheng
通讯作者：
Duh, Mei Sheng