Unveiling microbiome profiles in human inner body fluids and tumor tissues with pancreatic or biliary tract cancer.
Unveiling microbiome profiles in human inner body fluids and tumor tissues with pancreatic or biliary tract cancer.
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在人体内部流体和胰腺癌或胆道癌中揭示人体内部流体和肿瘤组织中的微生物组谱。
DOI：
10.1038/s41598-022-12658-8
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发表时间：
2022-05-24
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
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作者：
随着各种癌症组织中细菌共生的发现，肿瘤微生物组的研究引起了人们的极大关注。在解剖学上，由于胃肠道、肝脏和胰腺形成连续的导管结构，因此这些器官的消化液中的微生物组可能相互影响。在这里，我们报告了一系列肿瘤相关组织中的微生物组数据，如肿瘤，非肿瘤和淋巴结，以及胰腺癌或胆道癌患者的体液，如唾液，胃液，胰液，胆汁和粪便。结果表明，肿瘤相关组织的微生物组具有非常相似的细菌组成，但体液中的微生物组具有不同的细菌组成，这些细菌组成因位置而异，其中一些细菌定位于特定的体液。令人惊讶的是，Akkermansia仅在胆道癌患者的胆汁中检测到，其存在与胆道外引流的性能显著相关（P = 0.041）。此外，我们发现体内深部肿瘤相关组织和体液中大多数是未知和未表征的细菌，这表明此类细菌可能是未来精确治疗的潜在目标。
With the discovery of bacterial symbiosis in the tissues of various cancers, the study of the tumor microbiome is attracting a great deal of attention. Anatomically, since the gastrointestinal tract, liver, and pancreas form a continuous ductal structure, the microbiomes in the digestive juices of these organs may influence each other. Here, we report a series of microbiome data in tumor-associated tissues such as tumor, non-tumor, and lymph nodes, and body fluids such as saliva, gastric juice, pancreatic juice, bile, and feces of patients with pancreatic or biliary tract cancers. The results show that the microbiome of tumor-associated tissues has a very similar bacterial composition, but that in body fluids has different bacterial composition which varies by location, where some bacteria localize to specific body fluids. Surprisingly, Akkermansia was only detected in the bile of patients with biliary tract cancer and its presence was significantly associated with the performance of external biliary drainage (P = 0.041). Furthermore, we found that tumor-associated tissues and body fluids in deep inner body are mostly inhabited by unidentified and uncharacterized bacteria, suggesting that such bacteria may be potential targets for precision therapy in the future.
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DOI：
10.1016/j.cgh.2018.07.012
发表时间：
2019-01
期刊：
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
影响因子：
--
作者：
Song M;Chan AT
通讯作者：
Chan AT
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
2.7
作者：
Matsuyama R;Yabusita Y;Homma Y;Kumamoto T;Endo I
通讯作者：
Endo I
影响因子：
14.9
作者：
Kaminuma E;Mashima J;Kodama Y;Gojobori T;Ogasawara O;Okubo K;Takagi T;Nakamura Y
通讯作者：
Nakamura Y
DOI：
10.1126/science.aao3290
发表时间：
2018-01-05
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Matson V;Fessler J;Bao R;Chongsuwat T;Zha Y;Alegre ML;Luke JJ;Gajewski TF
通讯作者：
Gajewski TF